High incidence of invasive fungal sinusitis in patients undergoing undergoing induction therapy for acute myeloid leukaemia or myelodysplasia with fludarabine and cytarabine based regimens: A retrospective analysis

摘要: Background Invasive fungal infections have been relatively well documented in stem cell transplantation4 (SCT) but not in the setting of intensive chemotherapy (ICT) alone. Aspergillus species are the commonest causative organism. Optimal treatment involves systemic antifungal therapy, combined with surgical debridement 1, 6. Reported mortality is 40-70% 5, 7 and long term morbidity approaches 70%. Aims We evaluated the impact, and differential incidence, of IFS in patients with de novo, relapsed or refractory acute myeloid leukemia (AML) or myelodysplasia (MDS) who received either fludarabine plus cytarabine (FLA) based induction chemotherapy or alternative ICT. Methods All