作者: MFA Karel , BME Tullemans , G D'Italia , TP Lemmens , TAM Claushuis
DOI:
关键词:
摘要: Bruton's kinase (Btk) is critical for collagen-triggered platelet signal transduction. The Btk inhibitor ibrutinib has been shown to selectively block platelet adhesion to atherosclerotic plaque material under laminar arterial flow. However, this has not been studied under a shear gradient, which is characteristic for atherothrombosis.