作者： SR Visuri , K Ness , J Dzenitis , B Benett , K Bettencourt
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摘要: At Lawrence Livermore National Laboratory (LLNL) we are developing instruments for the detection of biological agents with applications in clinical medicine and national security. These instruments make use of nucleic acid-and immuno-assay techniques for the detection of viruses, bacteria, and proteins. Instruments are designed to operate autonomously-continuously sampling the environment and performing assays; or operate on demand at the point-of-care. Samples are typically introduced to downstream sample preparation and detection in a liquid format. Aerosolized particles are captured into a buffer solution and delivered downstream. Human samples are inherently fluids (eg mucus, serum, urine). Environmental or clinical samples often contain significant amounts of background contaminants. In order to improve the sensitivity and performance of the assays, sample preparation steps need to be …