Role of Sorting Nexin 1 (SNX1) in the group I metabotropic glutamate receptor trafficking

摘要: G-protein-coupled receptors (GPCRs) are seven transmembrane receptors that transduce information provided by the extracellular stimuli into intracellular signals via their coupling with G-proteins. Activation of GPCR also triggers a variety of cellular and molecular mechanisms, viz., receptor desensitization and internalization. Due to the diversity in the GPCR regulation, each GPCR is unique and an extensively studied GPCR may not provide all the details about other GPCRs. Glutamate is a major excitatory neurotransmitter in the central nervous system. It activates three types of receptors, viz., NMDARs, AMPARs and metabotropic glutamate receptors (mGluRs). Among these three types of receptors, mGluRs belong to the GPCR family. Among the eight subtypes of mGluRs, mGluR1 and mGluR5 belong to the group I family. These receptors play important roles in the brain and are believed to be involved in …