Cyclin A and B1 are overexpressed in thyroid cancers which had been operated for indeterminate, nondiagnostic, or suspicious fine-needle aspirate results

摘要: Objective: Approximately 30% of patients with thyroid nodules have indeterminate, nondiagnostic, or suspicious fine-needle aspiration (FNA) biopsy results. These patients usually undergo thyroidectomy because of cancer risk. Our aim was to determine diagnostic markers to distinguish benign from malignant thyroid neoplasms, so we focused on G2-M boundary regulators of the cell cycle and investigated the expression of two proteins, cyclin A and cyclin B1.Methods: We studied the expression of cyclin A and B1 in resection specimens of 168 indeterminate, nondiagnostic, or suspicious FNA biopsy results retrospectively using immunohistochemistry.Results: Sixty-four of resection specimens were consisted of malignant histopathology. Of 64 cases of thyroid cancer (58 papillary, 4 follicular, 1 medullary, and 1 hürthle cell carcinoma), cyclin A was overexpressed in 33 cases (51.5%) in contrast to 33 cases (31.7%) of …