INVESTIGATING THE INFLUENCE OF ATORVASTATIN ANTIOXIDANTS IN REDUCTION OF THE CARDIOTOXICITY OF ANTHRACYCLINE MEDICINES IN TREATING PATIENTS UNDERGOING CHEMOTHERAPY

摘要: The rise and increase in the number of cancers has resulted in the greater use of chemotherapy medicines. Anthracycline is one of the widely used chemotherapic medicines. Although this medicine is really effective on cancer cells, it has side effects such as cardiotoxicity. The present research seeks to study the influence of Atorvastatin Antioxidants in reduction of the cardiotoxicity caused by anthracycline among 215 patients who had resorted to Imam Reza Hospital (PBUH). The patients were divided into the case and testifier group. Those in the testifier group received no doze of Atorvastatin, while the case group received 20 mg of this antioxidant every day. In the 0 th, 3 rd, and 6 th months, patients were examined through ECG, Echocardiography, and clinical examinations so as to check the progress of Cardiomyopathy. The causes which contributed to the EF reduction of LV, symptoms of heart failure and development of heart failure were checked among them. After the information about each patient was collected, SPSS was used to analyze the data. 9 cases of cardiomyopathy were recorded. One of these cases was observed in the case group, while 8 were seen among those in the testifier group. This difference was observed significantly in two groups (p< 0.05). Considering the results obtained in this research, it was shown that Atorvastatin antioxidant has an effective