Serotype-specific microvascular changes in the liver due to dengue virus (DENV) non-structural protein-1 (NS1)

摘要: Funding Acknowledgements Type of funding sources: Public Institution(s). Main funding source(s): University of Surrey Dengue virus is the most common arbovirus in humans worldwide, with a minor proportion developing severe dengue, which includes the cardiovascular complications of vascular leakage, haemorrhage, organ failure and shock, all of which could prove fatal. The mechanisms that lead to microvascular leakage remain incompletely understood. While DENV-2 NS1 has been shown by our group to disrupt endothelial-pericyte interactions leading to enhanced endothelial cell permeability in vitro, it is unclear whether this is true across all four serotypes of DENV and to what degree. It is also unclear whether DENV NS1 similarly affects all types of pericytes across the body. Our previous work was performed in saphenous venous pericytes, which we here extend to include hepatic …