Design and Evaluation of Buccoadhesive Microspheres for Smoking Cessation

摘要: The present research work was designed with an aim to develop and evaluate buccoadhesive microspheres by cross linking method and determine the suitability of the formulation in nicotine replacement therapy. The developed microspheres were evaluated for various physicochemical parameters like appearance, particle size distribution, DSC studies, angle of repose, drug content, mucoadhesion time, in vitro release behaviour and ex vivo drug permeation through porcine buccal mucosa. The release kinetics was further explored by using Korsmeyer-Peppas equation. Stability studies of optimized batches of microspheres were carried out as per ICH guidelines. The optimized batch was found to have the particle size between 100–150 μm and angle of repose 28.34±0.2, thus showing good flowability. The DSC thermogram revealed the engulfment of the drug into microspheres. The drug content of all the …