Ketamine Potentiates AMPA Receptor-mediated Activity in the Somatosensory Cortex

作者: Bushra Yasin , Damian J Williams , Carla Troyas , Neil L Harrison , Christopher D Makinson

DOI:

关键词:

摘要: Despite nearly five decades of clinical use, a mechanistic description of ketamine’s ability to reliably produce anesthesia for surgery has been elusive. Ketamine is classified as a “dissociative anesthetic” because it produces a markedly distinct anesthetized state compared to other anesthetic drugs. Furthermore, ketamine acts by increasing the high-frequency oscillations in the beta-gamma range, which is distinct from γ-aminobutyric acid–mediated (GABAergic) anesthetics. 1 Ketamine was thought to exert its anesthetic effect by acting as a non-competitive antagonist of N-methyl-D-aspartate (NMDA) receptors. 2, 3 However, the lack of anesthetic effects with MK-801, a non-competitive NMDA receptor antagonist structurally similar to ketamine, suggests that NMDAR antagonism may not be the primary mechanism for ketamine anesthesia. Ketamine also affects α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid …

参考文章(0)