Language and Epilepsy: A Systems Issue

摘要: Disorganization of Language and Working Memory Systems in Frontal Versus Temporal Lobe Epilepsy Caciagli L, Paquola C, He X, Vollmar C, Centeno M, Wandschneider B, Braun U, Trimmel K, Vos SB, Sidhu MK, Thompson PJ, Baxendale, S, Winston GP, Duncan JS, Bassett DS, Koepp MJ, Bernhardt BC. Brain. 2022;awac150. doi:10.1093/brain/awac150Cognitive impairment is a common comorbidity of epilepsy, and adversely impacts people with both frontal lobe epilepsy (FLE) and temporal lobe epilepsy (TLE). While its neural substrates have been extensively investigated in TLE, functional imaging studies in FLE are scarce. In this study, we profiled the neural processes underlying cognitive impairment in FLE, and directly compared FLE and TLE to establish commonalities and differences. We investigated 172 adult participants (56 with FLE, 64 with TLE, and 52 controls) using neuropsychological tests and …