Methylation classifier array and classification of solitary fibrous tumors.

摘要: e23522Background: Solitary fibrous tumors (SFTs) are fibroblastic tumors which carry a characteristic NAB2::STAT6 gene rearrangement. SFTs represent a heterogenous group that may arise in multiple locations and have variable risk of progression. Despite a consistent oncogenic driver, there is little biological data explaining this variability. Recently, the German Cancer Research Network (DKFZ) have modified their brain tumor methylation classifier for use in sarcomas. We subjected solitary fibrous tumors diagnosed at our institution to a validated, in-house sarcoma methylation array classifier modeled after that of the DKFZ in order to assess for differences in methylation patterns that may account for biological or clinical variances. Methods: Twenty-eight primary site SFTs from 2011-2021 were subjected to the sarcoma methylation classifier. Histologic diagnosis was confirmed by STAT6 immunohistochemistry …