Synthetic Metallobacteriochlorins with Site-specific Isotopic Substitution for Probing Photosynthetic Function

摘要: Bacteriochlorophylls–natural pigments for absorption of near-infrared (NIR) light–underlie light-absorption and energy transduction in photosynthetic bacteria. Understanding photosynthetic function including the capture and utilization of light is essential for applications ranging from artificial photosynthesis to photomedicine (photodynamic therapy, imaging, and diagnostics). Previous synthetic limitations have largely precluded access to bacteriochlorin model compounds suitable for probing photosynthetic function. A recently developed de novo synthesis of stable bacteriochlorins employs the self-condensation of a dihydrodipyrrin–acetal, which is prepared from simple precursors such as a pyrrole-2-carboxaldehye and an α, β-unsaturated ketone–acetal. The success of the de novo synthesis to synthetic bacteriochlorins has opened the door to the study of fundamental properties and pursuit of a range of …