QSAR Study of Some Anti-Hepatitis B Virus Agents Comprising 4-Aryl-6-Chloro-Quinolin-2-Ones and 5-Aryl-7-Chloro-1, 4-Benzodiazepines

摘要: QSAR analysis on a set of synthesized 4-Aryl-6-chloro-quinolin-2-ones and 5-Aryl-7-Chloro-1, 4-benzodiazepines analogues tested fir growth inhibitory antiviral activity was performed by using MLR procedure. The activity contributions of these compounds were determined from regression equation and the validation procedures to analyze the predictive ability of QSAR models were described. The results are discussed on the basis of statistical data. High agreements between experimental and predicted antiviral activity inhibitory values are obtained. The results of this study indicate that the substitution of electron withdrawing group, aromatic ring, polarizability etc. parameters has significant effect on antiviral activity of this class of compounds thus simplifying design of new biological active molecule.