Telomere length, telomerase activity, and structural variants as biomarkers of extreme environments

摘要: DISSERTATION TELOMERE LENGTH, TELOMERASE ACTIVITY, AND STRUCTURAL VARIANTS AS BIOMARKERS OF EXTREME ENVIRONMENTS Submitted by M Page 1 DISSERTATION TELOMERE LENGTH, TELOMERASE ACTIVITY, AND STRUCTURAL VARIANTS AS BIOMARKERS OF EXTREME ENVIRONMENTS Submitted by Miles J. McKenna Graduate Degree Program in Cell and Molecular Biology In partial fulfillment of the requirements For the Degree of Doctor of Philosophy Colorado State University Fort Collins, Colorado Summer 2017 Doctoral Committee: Advisor: Susan M. Bailey Steven Dow Takamitsu Kato Steven Simon Douglas Thamm Page 2 Copyright by Miles Joseph McKenna 2017 All Rights Reserved Page 3 ii ABSTRACT TELOMERE LENGTH, TELOMERASE ACTIVITY, AND STRUCTURAL VARIANTS AS BIOMARKERS OF EXTREME ENVIRONMENTS Mammals, and in particular …