Clinical Characteristics of Breast Cancer Patients with Lung Changes Following Intensity Modulated Proton Therapy

摘要: Purpose/Objective(s)To evaluate clinical characteristics and symptoms in patients with lung changes following intensity modulated proton therapy (IMPT) for breast cancer.Materials/MethodsFrom a cohort of 107 patients treated with IMPT for breast cancer from 7/2019 – 12/2022, 45 patients were retrospectively identified with subsequent CT lung imaging changes during follow-up appointments. Ipsilateral lung constraint was typically V20Gy < 20%. Treatment details including type of surgery and utilization of chemotherapy, patient reported respiratory symptoms, development of rib fractures, and treatment planning details were abstracted. The areas of lung density changes on follow-up imaging were contoured to quantify volume of change. CTCAE V5 pneumonitis scoring was assigned at any point after completion of IMPT.ResultsAmong the 45 patients, the average volume of post-radiation lung changes was 34 cc …