Chimeric mutants of staphylococcal hemolysin, which act as both one‐component and two‐component hemolysin, created by grafting the stem domain
Nouran Ghanem , Natsuki Kanagami , Takashi Matsui , Kein Takeda
The FEBS Journal 289 ( 12) 3505 -3520
4
2022
Fully differentiable full-atom protein backbone generation
Po-Ssu Huang , Namrata Anand , Raphael Eguchi
international conference on learning representations
37
2019
Optical control of fast and processive engineered myosins in vitro and in living cells.
Jan T. Liphardt , Gregory M. Alushin , Rajarshi P. Ghosh , Po-Ssu Huang
Nature Chemical Biology 17 ( 5) 540 -548
5
2021
Macromolecular modeling and design in Rosetta: recent methods and frameworks
Christoffer Norn , Shane Ó’Conchúir , Noah Ollikainen , Sergey Ovchinnikov
Nature Methods 17 ( 7) 665 -680
321
2020
Computational design and experimental verification of a symmetric protein homodimer
Yun Mou , Po-Ssu Huang , Fang-Ciao Hsu , Shing-Jong Huang
Proceedings of the National Academy of Sciences of the United States of America 112 ( 34) 10714 -10719
26
2015
Refocussing Antibody Responses by Chemical Modification of Vaccine Antigens
Torben Schiffner , Karolis Leonavicius , Heiko Schuster , Helen J. Kim
AIDS Research and Human Retroviruses 30
2014
HIV-1 VRC01 Germline-Targeting Immunogens Select Distinct Epitope-Specific B Cell Receptors.
Yu-Ru Lin , K. Rachael Parks , Connor Weidle , Anika S. Naidu
Immunity 53 ( 4)
1
2020
High thermodynamic stability of parametrically designed helical bundles.
Po-Ssu Huang , Gustav Oberdorfer , Chunfu Xu , Xue Y. Pei
Science 346 ( 6208) 481 -485
172
2014
Adaptation of a fast Fourier transform-based docking algorithm for protein design.
Po-Ssu Huang , John J. Love , Stephen L. Mayo
Journal of Computational Chemistry 26 ( 12) 1222 -1232
27
2005
Control of repeat-protein curvature by computational protein design.
Keunwan Park , Betty W Shen , Fabio Parmeggiani , Po-Ssu Huang
Nature Structural & Molecular Biology 22 ( 2) 167 -174
59
2015
Accurate de novo design of hyperstable constrained peptides.
Gaurav Bhardwaj , Vikram Khipple Mulligan , Christopher D Bahl , Jason M Gilmore
Nature 538 ( 7625) 329 -335
328
2016
The coming of age of de novo protein design
Po-Ssu Huang , Scott E. Boyken , David Baker
Nature 537 ( 7620) 320 -327
1,046
2016
Engineering a potent receptor superagonist or antagonist from a novel IL-6 family cytokine ligand
Jun W. Kim , Cesar P. Marquez , R. Andres Parra Sperberg , Jiaxiang Wu
Proceedings of the National Academy of Sciences of the United States of America 117 ( 25) 14110 -14118
3
2020
Computational design of closely related proteins that adopt two well-defined but structurally divergent folds.
Kathy Y. Wei , Danai Moschidi , Matthew J. Bick , Santrupti Nerli
Proceedings of the National Academy of Sciences of the United States of America 117 ( 13) 7208 -7215
22
2020
A Chimeric HIV-1 Envelope Glycoprotein Trimer with an Embedded Granulocyte-Macrophage Colony-stimulating Factor (GM-CSF) Domain Induces Enhanced Antibody and T Cell Responses
Thijs van Montfort , Mark Melchers , Gözde Isik , Sergey Menis
Journal of Biological Chemistry 286 ( 25) 22250 -22261
17
2011
Identification of N-Terminally Diversified GLP-1R Agonists Using Saturation Mutagenesis and Chemical Design.
Chelsea K. Longwell , Stephanie Hanna , Nina Hartrampf , R. Andres Parra Sperberg
ACS Chemical Biology 16 ( 1) 58 -66
2
2021
Designing repeat proteins: a modular approach to protein design.
Fabio Parmeggiani , Po-Ssu Huang
Current Opinion in Structural Biology 45 116 -123
21
2017
De novo design of a fluorescence-activating β-barrel
Jiayi Dou , Anastassia A. Vorobieva , William Sheffler , Lindsey A. Doyle
Nature 561 ( 7724) 485 -491
242
2018
A general computational approach for repeat protein design.
Fabio Parmeggiani , Po-Ssu Huang , Sergey Vorobiev , Rong Xiao
Journal of Molecular Biology 427 ( 2) 563 -575
61
2015
Computational de novo design of a self-assembling peptide with predefined structure.
Sabine Kaltofen , Chenge Li , Po-Ssu Huang , Louise C. Serpell
Journal of Molecular Biology 427 ( 2) 550 -562
13
2015