Eddy Arnold
机构: Board of Governors and Distinguished Professor of Chemistry and Chemical Biology, Rutgers University
每年引用次数
引用次数
引用: 33,321
H-指数: 98
I10-指数 : 258
出版物: 349
GE23077 binds to the RNA polymerase ‘i’ and ‘i+1’ sites and prevents the binding of initiating nucleotides
Yu Zhang , David Degen , Mary X Ho , Elena Sineva
eLife 3 ( 3)
57
2014
A bactericidal guanidinomethyl biaryl that alters the dynamics of bacterial FtsZ polymerization.
Malvika Kaul , Ajit K. Parhi , Yongzheng Zhang , Edmond J. LaVoie
Journal of Medicinal Chemistry 55 ( 22) 10160 -10176
38
2012
Detecting allosteric sites of HIV-1 reverse transcriptase by X-ray crystallographic fragment screening.
Joseph D. Bauman , Disha Patel , Chhaya Dharia , Marc W. Fromer
Journal of Medicinal Chemistry 56 ( 7) 2738 -2746
56
2013
Phenyl Substituted 4-Hydroxypyridazin-3(2H)-ones and 5-Hydroxypyrimidin-4(3H)-ones: Inhibitors of Influenza A Endonuclease
Hye Yeon Sagong , Joseph D. Bauman , Disha Patel , Kalyan Das
Journal of Medicinal Chemistry 57 ( 19) 8086 -8098
36
2014
Developing and Evaluating Inhibitors against the RNase H Active Site of HIV-1 Reverse Transcriptase.
Paul L. Boyer , Steven J. Smith , Xue Zhi Zhao , Kalyan Das
Journal of Virology 92 ( 13)
37
2018
Evolving understanding of HIV-1 reverse transcriptase structure, function, inhibition, and resistance.
Francesc Xavier RUIZ , Eddy Arnold
Current Opinion in Structural Biology 61 113 -123
32
2020
Taking aim at a moving target: designing drugs to inhibit drug-resistant HIV-1 reverse transcriptases.
Stefan G Sarafianos , Kalyan Das , Stephen H Hughes , Eddy Arnold
Current Opinion in Structural Biology 14 ( 6) 716 -730
120
2004
Structures of RNA polymerase-antibiotic complexes
Mary X Ho , Brian P Hudson , Kalyan Das , Eddy Arnold
Current Opinion in Structural Biology 19 ( 6) 715 -723
137
2009
Proteins: how RNA polymerases work.
Patrick Cramer , Eddy Arnold
Current Opinion in Structural Biology 19 ( 6) 680 -682
5
2009
Structure of a Dihydroxycoumarin Active-Site Inhibitor in Complex with the RNase H Domain of HIV-1 Reverse Transcriptase and Structure–Activity Analysis of Inhibitor Analogs
Daniel M. Himmel , Nataliya S. Myshakina , Tatiana Ilina , Alexander Van Ry
Journal of Molecular Biology 426 ( 14) 2617 -2631
38
2014
Extension into the entrance channel of HIV-1 reverse transcriptase—Crystallography and enhanced solubility
Mariela Bollini , Kathleen M. Frey , José A. Cisneros , Krasimir A. Spasov
Bioorganic & Medicinal Chemistry Letters 23 ( 18) 5209 -5212
34
2013
Why Do HIV-1 and HIV-2 Use Different Pathways to Develop AZT Resistance?
Paul L Boyer , Stefan G Sarafianos , Patrick K Clark , Eddy Arnold
PLOS Pathogens 2 ( 2) 101 -111
83
2006
Drug Resistance in Non-B Subtype HIV-1: Impact of HIV-1 Reverse Transcriptase Inhibitors
Kamalendra Singh , Jacqueline Flores , Karen Kirby , Ujjwal Neogi
Viruses 6 ( 9) 3535 -3562
22
2014
Alpha-carboxynucleoside phosphonates: direct-acting inhibitors of viral DNA polymerases
Jan Balzarini , Alan Ford , Nuala M Maguire , Jubi John
Future Medicinal Chemistry 11 ( 2) 137 -154
3
2019
Structures of Wild-Type and AZT-Resistant HIV-1 Reverse Transcriptase Complexed with AZTppppA Yield Insights into the Nucleotide Excision Mechanism
Xiongying Tu , Stefan G Sarafianos , Qianwei Han , Kalyan Das
The FASEB Journal 21 ( 5)
2007
Structural Basis for the Role of the K65R Mutation in HIV-1 Reverse Transcriptase Polymerization, Excision Antagonism, and Tenofovir Resistance
Kalyan Das , Rajiv P Bandwar , Kirsten L White , Joy Y Feng
Journal of Biological Chemistry 284 ( 50) 35092 -35100
76
2009
Design, synthesis, and SAR of a novel pyrazinone series with non-nucleoside HIV-1 reverse transcriptase inhibitory activity.
Jan Heeres , Marc R. de Jonge , Lucien M. H. Koymans , Frits F. D. Daeyaert
Journal of Medicinal Chemistry 48 ( 6) 1910 -1918
40
2005
Synthesis of novel diarylpyrimidine analogues and their antiviral activity against human immunodeficiency virus type 1.
Jerome Guillemont , Elisabeth Pasquier , Patrice Palandjian , Daniel Vernier
Journal of Medicinal Chemistry 48 ( 6) 2072 -2079
100
2005
4-Benzyl and 4-benzoyl-3-dimethylaminopyridin-2(1H)-ones: in vitro evaluation of new C-3-amino-substituted and C-5,6-alkyl-substituted analogues against clinically important HIV mutant strains.
Abdellah Benjahad , Martine Croisy , Claude Monneret , Emile Bisagni
Journal of Medicinal Chemistry 48 ( 6) 1948 -1964
34
2005
In search of a novel anti-HIV drug: multidisciplinary coordination in the discovery of 4-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-2- pyrimidinyl]amino]benzonitrile (R278474, rilpivirine).
Paul A. J. Janssen , Paul J. Lewi , Eddy Arnold , Frits Daeyaert
Journal of Medicinal Chemistry 48 ( 6) 1901 -1909
403
2005