Designed protein pores as components for biosensors

Hagan Bayley , Orit Braha , John Kasianowicz , Eric Gouaux

1,337
2005
Principles of selective ion transport in channels and pumps.

Eric Gouaux , Roderick MacKinnon
Science 310 ( 5753) 1461 -1465

933
2005
α-Hemolysin fromStaphylococcus aureus: an archetype of β-barrel, channel-forming toxins

Eric Gouaux
Journal of structural biology 121 ( 2) 110 -122

321
1998
Mechanism of positive allosteric modulators acting on AMPA receptors.

Rongsheng Jin , Suzanne Clark , Autumn M Weeks , Joshua T Dudman
The Journal of Neuroscience 25 ( 39) 9027 -9036

185
2005
Designed protein pores as components for biosensors

Hagan Bayley , Orit Braha , John Kasianowicz , Eric Gouaux

133
2004
Illumination of serotonin transporter mechanism and role of the allosteric site

Dongxue Yang , Eric Gouaux
Science Advances 7 ( 49) eabl3857 -eabl3857

84
2021
Vibrio cholerae cytolysin is composed of an α‐hemolysin‐like core

Rich Olson , Eric Gouaux
Protein science 12 ( 2) 379 -383

54
2003
The antidepressant drug vilazodone is an allosteric inhibitor of the serotonin transporter

Per Plenge , Dongxue Yang , Kristine Salomon , Louise Laursen
Nature Communications 12 ( 1) 5063 -5063

51
2021
Architecture and assembly mechanism of native glycine receptors

Hongtao Zhu , Eric Gouaux
Nature 599 ( 7885) 513 -517

45
2021
X-ray structure of AMPA-subtype glutamate receptor: symmetry and mechanism

Alexander I Sobolevsky , Michael P Rosconi , Eric Gouaux
Nature 462 ( 7274) 745 -745

18
2009
X-ray structure of the dopamine transporter in complex with tricyclic antidepressant

Aravind Penmatsa , Kevin H Wang , Eric Gouaux
Nature 503 ( 7474) 85 -85

15
2013
Cryo-EM structures reveal native GABAA receptor assemblies and pharmacology

Chang Sun , Hongtao Zhu , Sarah Clark , Eric Gouaux
Nature 622 ( 7981) 195 -201

11
2023
Extracellular loops of the serotonin transporter act as a selectivity filter for drug binding

Eray Esendir , Verena Burtscher , Jonathan A Coleman , Rong Zhu
Journal of Biological Chemistry 297 ( 1)

11
2021
Lipids lost, lipids regained.

Eric Gouaux , Stephen H White
Current Opinion in Structural Biology 11 ( 4) 393 -396

5
2001
Molecular structures and conformations of protocadherin-15 and its complexes on stereocilia elucidated by cryo-electron tomography

Johannes Elferich , Sarah Clark , Jingpeng Ge , April Goehring
Elife 10 e74512 -e74512

7
2021
Regulated assembly and neurosteroid modulation constrain GABAA receptor pharmacology in vivo

Chang Sun , Hongtao Zhu , Sarah Clark , Eric Gouaux
bioRxiv 2023.02. 16.528867 -2023.02. 16.528867

5
2023
Aminomethanesulfonic acid illuminates the boundary between full and partial agonists of the pentameric glycine receptor

Josip Ivica , Hongtao Zhu , Remigijus Lape , Eric Gouaux
Elife 11 e79148 -e79148

4
2022
Large-scale growth of C. elegans and isolation of membrane protein complexes

Sarah Clark , Hanbin Jeong , April Goehring , Yunsik Kang
Nature Protocols 18 ( 9) 2699 -2716

2
2023
2
2023