Ethan A Merritt
机构: Research Associate Professor, Biochemistry, University of Washington
主页: washington.edu
每年引用次数
引用次数
引用: 18,997
H-指数: 53
I10-指数 : 110
出版物: 150
The gatekeeper residue and beyond: homologous calcium-dependent protein kinases as drug development targets for veterinarian Apicomplexa parasites.
KATELYN R. KEYLOUN , MOLLY C. REID , RYAN CHOI , YIFAN SONG
Parasitology 141 ( 11) 1499 -1509
38
2014
Sequence determinants of a specific inactive protein kinase conformation.
Sanjay B. Hari , Ethan A. Merritt , Dustin J. Maly
Chemistry & Biology 20 ( 6) 806 -815
59
2013
Conformation-Selective ATP-Competitive Inhibitors Control Regulatory Interactions and Noncatalytic Functions of Mitogen-Activated Protein Kinases
Sanjay B. Hari , Ethan A. Merritt , Dustin J. Maly
Chemistry & Biology 21 ( 5) 628 -635
21
2014
Combating infectious diseases through multivalent design.
Erkang Fan , Ethan A Merritt
Current Drug Targets - Infectious Disorders 2 ( 2) 161 -167
9
2002
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MENACHEM SHOHAM , TALI SCHERF , JACOB ANGLISTER , MICHAEL LEVITT
CRYSTALLOGRAPHIC STUDIES OF METAL-POLYPHOSPHATE CHELATES AS MODELS FOR NUCLEOTIDE SUBSTRATE CONFORMATION.
Ethan Allen Merritt
0185 -0185
1982
COORDINATION OF TRIPHOSPHATE ION TO FORM AN 8-MEMBERED CHELATE RING
EA MERRITT , M SUNDARALINGAM , RD CORNELIUS
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 180 ( AUG) 41 -INOR
1980
The structure of tryptophanyl-tRNA synthetase from Giardia lamblia reveals divergence from eukaryotic homologs
Tracy L. Arakaki , Megan Carter , Alberto J. Napuli , Christophe L.M.J. Verlinde
Journal of Structural Biology 171 ( 2) 238 -243
9
2010
The crystal structure and activity of a putative trypanosomal nucleoside phosphorylase reveal it to be a homodimeric uridine phosphorylase.
Eric T. Larson , Devaraja G. Mudeppa , J. Robert Gillespie , Natascha Mueller
Journal of Molecular Biology 396 ( 5) 1244 -1259
16
2010
Crystal structures of trypanosomal histidyl-tRNA synthetase illuminate differences between eukaryotic and prokaryotic homologs.
Ethan A. Merritt , Tracy L. Arakaki , J. Robert Gillespie , Eric T. Larson
Journal of Molecular Biology 397 ( 2) 481 -494
33
2010
The double-length tyrosyl-tRNA synthetase from the eukaryote Leishmania major forms an intrinsically asymmetric pseudo-dimer.
Eric T. Larson , Jessica E. Kim , Lisa J. Castaneda , Alberto J. Napuli
Journal of Molecular Biology 409 ( 2) 159 -176
30
2011
X-ray crystal and molecular structure and absolute configuration of (dihydrogen tripolyphosphato) tetraamminecobalt(III) monohydrate, Co(NH3)4H2P3O10.H2O. A model for a metal-nucleoside polyphosphate complex.
Ethan A. Merritt , M. Sundaralingam , Richard D. Cornelius , W. W. Cleland
Biochemistry 17 ( 16) 3274 -3278
50
1978
TLSMD web server for the generation of multi-group TLS models
Jay Painter , Ethan A. Merritt
Journal of Applied Crystallography 39 ( 1) 109 -111
854
2006
High-resolution Structural and Thermodynamic Analysis of Extreme Stabilization of Human Procarboxypeptidase by Computational Protein Design
Gautam Dantas , Colin Corrent , Steve L. Reichow , James J. Havranek
Journal of Molecular Biology 366 ( 4) 1209 -1221
85
2007
Structures of substrate- and inhibitor-bound adenosine deaminase from a human malaria parasite show a dramatic conformational change and shed light on drug selectivity.
Eric T. Larson , Wei Deng , Brian E. Krumm , Alberto Napuli
Journal of Molecular Biology 381 ( 4) 975 -988
25
2008
Development of potent and selective Plasmodium falciparum calcium-dependent protein kinase 4 (PfCDPK4) inhibitors that block the transmission of malaria to mosquitoes.
Rama Subba Rao Vidadala , Kayode K. Ojo , Steven M. Johnson , Zhongsheng Zhang
European Journal of Medicinal Chemistry 74 562 -573
44
2014
Anchor-based design of improved cholera toxin and E. coli heat-labile enterotoxin receptor binding antagonists that display multiple binding modes.
Jason C. Pickens , Ethan A. Merritt , Misol Ahn , Christophe L.M.J. Verlinde
Chemistry & Biology 9 ( 2) 215 -224
40
2002
Development of Toxoplasma gondii calcium-dependent protein kinase 1 (TgCDPK1) inhibitors with potent anti-toxoplasma activity.
Steven M. Johnson , Ryan C. Murphy , Jennifer A. Geiger , Amy E. DeRocher
Journal of Medicinal Chemistry 55 ( 5) 2416 -2426
86
2012
Multiple Determinants for Selective Inhibition of Apicomplexan Calcium-Dependent Protein Kinase CDPK1.
Eric T. Larson , Kayode K. Ojo , Ryan C. Murphy , Steven M. Johnson
Journal of Medicinal Chemistry 55 ( 6) 2803 -2810
59
2012
Transmission of malaria to mosquitoes blocked by bumped kinase inhibitors
Kayode K. Ojo , Claudia Pfander , Natascha R. Mueller , Charlotte Burstroem
Journal of Clinical Investigation 122 ( 6) 2301 -2305
80
2012