CRYSTALLOGRAPHIC STUDIES OF METAL-POLYPHOSPHATE CHELATES AS MODELS FOR NUCLEOTIDE SUBSTRATE CONFORMATION.

摘要: Nucleotides are substrates for polymerases, kinases, phosphorylases, and cofactors for a host of catalytic enzymes. A knowledge of nucleotide structure and chemistry is thus a step toward understanding the mechanisms of enzyme function. The actual substrate for most of these enzymes is a compl