引用次数
引用: 3,415
H-指数: 31
I10-指数 : 42
出版物: 67
Structural Insights into FGFR Kinase Isoform Selectivity: Diverse Binding Modes of AZD4547 and Ponatinib in Complex with FGFR1 and FGFR4
Julie A. Tucker , Tobias Klein , Jason Breed , Alexander L. Breeze
Structure 22 ( 12) 1764 -1774
86
2014
Purification of a rat neurotensin receptor expressed in Escherichia coli.
Julie TUCKER , Reinhard GRISSHAMMER
Biochemical Journal 317 ( 3) 891 -899
208
1996
Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations.
Stephan Wilmes , Maximillian Hafer , Joni Vuorio , Julie A. Tucker
Science 367 ( 6478) 643 -652
34
2020
Cyclin-dependent kinase 4 inhibitors as a treatment for cancer. Part 2: identification and optimisation of substituted 2,4-bis anilino pyrimidines.
Gloria A. Breault , Rebecca P.A. Ellston , Stephen Green , S.Russell James
Bioorganic & Medicinal Chemistry Letters 13 ( 18) 2961 -2966
52
2003
Cyclin-Dependent Kinase 4 Inhibitors as a Treatment for Cancer. Part 1: Identification and Optimisation of Substituted 4,6-Bis Anilino Pyrimidines
John F. Beattie , Gloria A. Breault , Rebecca P.A. Ellston , Stephen Green
Bioorganic & Medicinal Chemistry Letters 13 ( 18) 2955 -2960
73
2003
Cell-Active Small Molecule Inhibitors of the DNA-Damage Repair Enzyme Poly(ADP-ribose) Glycohydrolase (PARG): Discovery and Optimization of Orally Bioavailable Quinazolinedione Sulfonamides.
Bohdan Waszkowycz , Kate M. Smith , Alison E. McGonagle , Allan M. Jordan
Journal of Medicinal Chemistry 61 ( 23) 10767 -10792
11
2018
Design and synthesis of novel lactate dehydrogenase A inhibitors by fragment-based lead generation.
Richard A. Ward , Claire Brassington , Alexander L. Breeze , Alessandro Caputo
Journal of Medicinal Chemistry 55 ( 7) 3285 -3306
123
2012
Keep it together: restraints in crystallographic refinement of macromolecule-ligand complexes
Roberto A. Steiner , Julie A. Tucker
Acta Crystallographica Section D-biological Crystallography 73 ( 2) 93 -102
14
2017
How Tyrosine 15 Phosphorylation Inhibits the Activity of Cyclin-Dependent Kinase 2-Cyclin A.
Julie P. I. Welburn , Julie A. Tucker , Tim Johnson , Lisa Lindert
Journal of Biological Chemistry 282 ( 5) 3173 -3181
75
2007
Paradoxical activation of the protein kinase-transcription factor ERK5 by ERK5 kinase inhibitors.
Pamela A. Lochhead , Julie A. Tucker , Natalie J. Tatum , Jinhua Wang
Nature Communications 11 ( 1) 1383
6
2020
Discovery of azabenzimidazole derivatives as potent, selective inhibitors of TBK1/IKKε kinases
Tao Wang , Michael A. Block , Scott Cowen , Audrey M. Davies
Bioorganic & Medicinal Chemistry Letters 22 ( 5) 2063 -2069
34
2012
Structural and dynamic insights into the energetics of activation loop rearrangement in FGFR1 kinase
Tobias Klein , Navratna Vajpai , Jonathan J. Phillips , Gareth Davies
Nature Communications 6 ( 1) 7877 -7877
28
2015
Thiazolopyridine Ureas as Novel Antitubercular Agents Acting through Inhibition of DNA Gyrase B.
Manoj G. Kale , Anandkumar Raichurkar , Shahul Hameed P , David Waterson
Journal of Medicinal Chemistry 56 ( 21) 8834 -8848
44
2013
Structure Guided Lead Generation for M. tuberculosis Thymidylate Kinase (Mtb TMK): Discovery of 3-Cyanopyridone and 1,6-Naphthyridin-2-one as Potent Inhibitors
Maruti Naik , Anandkumar Raichurkar , Balachandra S. Bandodkar , Begur V. Varun
Journal of Medicinal Chemistry 58 ( 2) 753 -766
42
2015
Small Molecule Binding Sites on the Ras:SOS Complex Can be Exploited for Inhibition of Ras Activation.
Jon J. G. Winter , Malcolm Anderson , Kevin Blades , Claire Brassington
Journal of Medicinal Chemistry 58 ( 5) 2265 -2274
70
2015
Probing the ATP Ribose-Binding Domain of Cyclin-Dependent Kinases 1 and 2 with O(6)-Substituted Guanine Derivatives
Ashleigh E Gibson , Christine E Arris , Johanne Bentley , F Thomas Boyle
Journal of Medicinal Chemistry 45 ( 16) 3381 -3393
110
2002
Small molecule ERK5 kinase inhibitors paradoxically activate ERK5 signalling: be careful what you wish for….
Simon J. Cook , Julie A. Tucker , Pamela A. Lochhead
Biochemical Society Transactions 48 ( 5) 1859 -1875
2
2020
Structure-based design of a potent purine-based cyclin-dependent kinase inhibitor
Thomas G Davies , Johanne Bentley , Christine E Arris , F Thomas Boyle
Nature Structural & Molecular Biology 9 ( 10) 745 -749
264
2002
Structures of the Human Poly (ADP-Ribose) Glycohydrolase Catalytic Domain Confirm Catalytic Mechanism and Explain Inhibition by ADP-HPD Derivatives
Julie A. Tucker , Neil Bennett , Claire Brassington , Stephen T. Durant
PLoS ONE 7 ( 12) e50889
38
2012
Imidazole piperazines: SAR and development of a potent class of cyclin-dependent kinase inhibitors with a novel binding mode
M Raymond V Finlay , David G Acton , David M Andrews , Andrew J Barker
Bioorganic & Medicinal Chemistry Letters 18 ( 15) 4442 -4446
26
2008