Mutant-selective degradation by BRAF-targeting PROTACs.
Craig M. Crews , Neal Rosen , Zhan Yao , Yijun Gao
Nature Communications 12 ( 1) 920 -920
53
2021
Nucleophosmin/B23 Inhibits Eg5-mediated Microtubule Depolymerization by Inactivating Its ATPase Activity
Guoxing Wang , Xiang Gao , Yun Huang , Zhan Yao
Journal of Biological Chemistry 285 ( 25) 19060 -19067
16
2010
Phenformin Enhances the Efficacy of ERK Inhibition in NF1-Mutant Melanoma
Sebastian Trousil , Shuang Chen , Chan Mu , Fiona M. Shaw
Journal of Investigative Dermatology 137 ( 5) 1135 -1143
15
2017
Intermittent Treatment With MEK Inhibitors in Patients With Oncogenic RAF-Driven Tumors: A Potential Strategy to Manage Toxicity and Maintain Efficacy
Rona Yaeger , Zhan Yao , Paul B. Chapman
JCO Precision Oncology ( 2) 1 -2
2
2018
V211D Mutation in MEK1 Causes Resistance to MEK Inhibitors in Colon Cancer.
Yijun Gao , Ann Maria , Na Na , Arnaud da Cruz Paula
Cancer Discovery 9 ( 9) 1182 -1191
10
2019
Allele-Specific Mechanisms of Activation of MEK1 Mutants Determine Their Properties
Yijun Gao , Matthew T. Chang , Daniel McKay , Na Na
Cancer Discovery 8 ( 5) 648 -661
2018
A Secondary Mutation in BRAF Confers Resistance to RAF Inhibition in a BRAFV600E-Mutant Brain Tumor
Jiawan Wang , Zhan Yao , Philip Jonsson , Amy N. Allen
Cancer Discovery 8 ( 9) 1130 -1141
25
2018
A Braf kinase-inactive mutant induces lung adenocarcinoma
Patricia Nieto , Chiara Ambrogio , Laura Esteban-Burgos , Gonzalo Gómez-López
Nature 548 ( 7666) 239 -243
52
2017
Tumours with class 3 BRAF mutants are sensitive to the inhibition of activated RAS
Zhan Yao , Rona Yaeger , Vanessa S. Rodrik-Outmezguine , Anthony Tao
Nature 548 ( 7666) 234 -238
375
2017
Mechanistically distinct cancer-associated mTOR activation clusters predict sensitivity to rapamycin
Jianing Xu , Can G. Pham , Steven K. Albanese , Yiyu Dong
Journal of Clinical Investigation 126 ( 9) 3526 -3540
56
2016
RAF inhibitor PLX8394 selectively disrupts BRAF dimers and RAS-independent BRAF-mutant-driven signaling
Zhan Yao , Yijun Gao , Wenjing Su , Rona Yaeger
Nature Medicine 25 ( 2) 284 -291
120
2019
Rapid induction of apoptosis by PI3K inhibitors is dependent upon their transient inhibition of RAS-ERK signaling
Marie Will , Alice Can Ran Qin , Weiyi Toy , Zhan Yao
Cancer Discovery 4 ( 3) 334 -347
121
2014
Diverse and Targetable Kinase Alterations Drive Histiocytic Neoplasms
Eli L. Diamond , Benjamin H. Durham , Julien Haroche , Zhan Yao
Cancer Discovery 6 ( 2) 154 -165
211
2016
Mechanisms of Acquired Resistance to BRAF V600E Inhibition in Colon Cancers Converge on RAF Dimerization and Are Sensitive to Its Inhibition
Rona Yaeger , Zhan Yao , David M. Hyman , Jaclyn F. Hechtman
Cancer Research 77 ( 23) 6513 -6523
61
2017
BRAF Mutants Evade ERK-Dependent Feedback by Different Mechanisms that Determine Their Sensitivity to Pharmacologic Inhibition
Zhan Yao , Neilawattie M. Torres , Anthony Tao , Yijun Gao
Cancer Cell 28 ( 3) 370 -383
217
2015
Loss of NF1 in cutaneous melanoma is associated with RAS activation and MEK dependence
Moriah H. Nissan , Christine A. Pratilas , Alexis M. Jones , Ricardo Ramirez
Cancer Research 74 ( 8) 2340 -2350
178
2014
TGF-β reduces DNA ds-break repair mechanisms to heighten genetic diversity and adaptability of CD44+/CD24- cancer cells
Debjani Pal , Anja Pertot , Nitin H Shirole , Zhan Yao
eLife 6
19
2017
A brain-penetrant RAF dimer antagonist for the noncanonical BRAF oncoprotein of pediatric low-grade astrocytomas.
Yu Sun , John A. Alberta , Catherine Pilarz , David Calligaris
Neuro-oncology 19 ( 6) 774 -785
40
2017
Death effector domain DEDa, a self-cleaved product of caspase-8/Mch5, translocates to the nucleus by binding to ERK1/2 and upregulates procaspase-8 expression via a p53-dependent mechanism.
Zhan Yao , Shanshan Duan , Dezhi Hou , Klaus Heese
The EMBO Journal 26 ( 4) 1068 -1080
25
2007