TGF-β reduces DNA ds-break repair mechanisms to heighten genetic diversity and adaptability of CD44+/CD24- cancer cells

作者： Debjani Pal , Anja Pertot , Nitin H Shirole , Zhan Yao , Naishitha Anaparthy

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摘要: Many lines of evidence have indicated that both genetic and non-genetic determinants can contribute to intra-tumor heterogeneity influence cancer outcomes. Among the best described sub-population cells generated by mechanisms are characterized a CD44+/CD24- cell surface marker profile. Here, we report human genetically highly unstable because intrinsic defects in their DNA-repair capabilities. In fact, cells, constitutive activation TGF-beta axis was necessary sufficient reduce expression genes crucial coordinating DNA damage repair mechanisms. Consequently, observed reside state increased accumulation copy number alterations, greater diversity improved adaptability drug treatment. Together, these data suggest transition into promote heterogeneity, spur tumor evolution increase fitness.

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参考文章(72)

浩平宮園, Rik Derynck, The TGF-β Family Cold Spring Harbor Laboratory Press. ,(2008)

A O Pisco, S Huang, Non-genetic cancer cell plasticity and therapy-induced stemness in tumour relapse: 'What does not kill me strengthens me'. British Journal of Cancer. ,vol. 112, pp. 1725- 1732 ,(2015) , 10.1038/BJC.2015.146

Sandra Morandell, Michael B. Yaffe, Exploiting synthetic lethal interactions between DNA damage signaling, checkpoint control, and p53 for targeted cancer therapy. Progress in Molecular Biology and Translational Science. ,vol. 110, pp. 289- 314 ,(2012) , 10.1016/B978-0-12-387665-2.00011-0

Michael D. Brooks, Monika L. Burness, Max S. Wicha, Therapeutic Implications of Cellular Heterogeneity and Plasticity in Breast Cancer Cell Stem Cell. ,vol. 17, pp. 260- 271 ,(2015) , 10.1016/J.STEM.2015.08.014

Ian R. Hart, Stephen Mitchell, Mary Birch, Isolation and characterization of human melanoma cell variants expressing high and low levels of CD44. Cancer Research. ,vol. 51, pp. 6660- 6667 ,(1991)

Naoki Oshimori, Elaine Fuchs, Paracrine TGF-β Signaling Counterbalances BMP-Mediated Repression in Hair Follicle Stem Cell Activation Cell Stem Cell. ,vol. 10, pp. 63- 75 ,(2012) , 10.1016/J.STEM.2011.11.005

Melanie L. Mayer, Steven P. Gygi, Ruedi Aebersold, Philip Hieter, Identification of RFC(Ctf18p, Ctf8p, Dcc1p): an alternative RFC complex required for sister chromatid cohesion in S. cerevisiae. Molecular Cell. ,vol. 7, pp. 959- 970 ,(2001) , 10.1016/S1097-2765(01)00254-4

Ford, D, Easton, DF, Bishop, DT, Narod, SA, Goldgar, DE and the Breast Cancer Linkage Consortium, None, Risks of cancer in BRCA1-mutation carriers The Lancet. ,vol. 343, pp. 692- 695 ,(1994) , 10.1016/S0140-6736(94)91578-4

Alice X. Meng, Farid Jalali, Andrew Cuddihy, Norman Chan, Ranjit S. Bindra, Peter M. Glazer, Robert G. Bristow, Hypoxia down-regulates DNA double strand break repair gene expression in prostate cancer cells. Radiotherapy and Oncology. ,vol. 76, pp. 168- 176 ,(2005) , 10.1016/J.RADONC.2005.06.025

10.

M Jain, Q He, W S Lee, S Kashiki, L C Foster, J C Tsai, M E Lee, E Haber, Role of CD44 in the reaction of vascular smooth muscle cells to arterial wall injury. Journal of Clinical Investigation. ,vol. 97, pp. 596- 603 ,(1996) , 10.1172/JCI118455

TGF-β reduces DNA ds-break repair mechanisms to heighten genetic diversity and adaptability of CD44+/CD24- cancer cells

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TGF-β reduces DNA ds-break repair mechanisms to heighten genetic diversity and adaptability of CD44+/CD24- cancer cells

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