Prevalence and role of HER2 mutations in cancer.
Emiliano Cocco , Salvatore Lopez , Alessandro D. Santin , Maurizio Scaltriti
Pharmacology & Therapeutics 199 188 -196
10
2019
Efficacy and Determinants of Response to HER Kinase Inhibition in HER2-Mutant Metastatic Breast Cancer
Lillian M. Smyth , Sarina A. Piha-Paul , Helen H. Won , Alison M. Schram
Cancer Discovery 10 ( 2) 198 -213
73
2020
HER2-Mediated Internalization of Cytotoxic Agents in ERBB2 Amplified or Mutant Lung Cancers
Bob T. Li , Flavia Michelini , Sandra Misale , Emiliano Cocco
Cancer Discovery 10 ( 5) 674 -687
20
2020
TRK xDFG Mutations Trigger a Sensitivity Switch from Type I to II Kinase Inhibitors
Moshe Elkabets , Elisa de Stanchina , Chandra S. Verma , Andrea Ventura
Cancer Discovery 11 ( 1) 126 -141
5
2021
A Next-Generation TRK Kinase Inhibitor Overcomes Acquired Resistance to Prior TRK Kinase Inhibition in Patients with TRK Fusion-Positive Solid Tumors.
Alexander Drilon , Ramamoorthy Nagasubramanian , James F. Blake , Nora Ku
Cancer Discovery 7 ( 9) 963 -972
310
2017
Genetic Predictors of Response to Systemic Therapy in Esophagogastric Cancer.
Yelena Y. Janjigian , Francisco Sanchez-Vega , Philip Jonsson , Walid K. Chatila
Cancer Discovery 8 ( 1) 49 -58
126
2018
EGFR and MET Amplifications Determine Response to HER2 Inhibition in ERBB2-Amplified Esophagogastric Cancer
Francisco Sanchez-Vega , Jaclyn F. Hechtman , Pau Castel , Geoffrey Y. Ku
Cancer Discovery 9 ( 2) 199 -209
43
2019
CDK 4/6 Inhibition Overcomes Acquired and Inherent Resistance to PI3Kα Inhibition in Pre-Clinical Models of Head and Neck Squamous Cell Carcinoma.
Eric Remer , Mai Badarni , Elad Hikri , Avraham Dayan
Journal of Clinical Medicine 9 ( 10) 3214
2
2020
PIM1 kinase regulates cell death, tumor growth and chemotherapy response in triple-negative breast cancer
Fara Brasó-Maristany , Simone Filosto , Steven Catchpole , Rebecca Marlow
Nature Medicine 22 ( 11) 1303 -1313
190
2017
NTRK fusion-positive cancers and TRK inhibitor therapy
Emiliano Cocco , Maurizio Scaltriti , Alexander Drilon
Nature Reviews Clinical Oncology 15 ( 12) 731 -747
911
2018
A Major Role of p95/611-CTF, a Carboxy-Terminal Fragment of HER2, in the Down-modulation of the Estrogen Receptor in HER2-Positive Breast Cancers
Josep Lluís Parra-Palau , Kim Pedersen , Vicente Peg , Maurizio Scaltriti
Cancer Research 70 ( 21) 8537 -8546
45
2010
Phosphatidylinositol 3-Kinase Hyperactivation Results in Lapatinib Resistance that Is Reversed by the mTOR/Phosphatidylinositol 3-Kinase Inhibitor NVP-BEZ235
Pieter J.A. Eichhorn , Magüi Gili , Maurizio Scaltriti , Violeta Serra
Cancer Research 68 ( 22) 9221 -9230
428
2008
Antitumor activity of the Hsp90 inhibitor IPI-504 in HER2-positive trastuzumab-resistant breast cancer.
Maurizio Scaltriti , Violeta Serra , Emmanuel Normant , Marta Guzman
Molecular Cancer Therapeutics 10 ( 5) 817 -824
36
2011
Quantification of HER family receptors in breast cancer
Paolo Nuciforo , Nina Radosevic-Robin , Tony Ng , Maurizio Scaltriti
Breast Cancer Research 17 ( 1) 53 -53
29
2015
Abstract NG16: Double PIK3CA mutations in cis increase oncogenicity and sensitivity to PI3Kα inhibitors
Neil Vasan , Pedram Razavi , Jared L. Johnson , Hong Shao
Cancer Research 80
2020
Therapeutic Antibodies in Breast Cancer
José Pérez-Garcia , Eva Muñoz-Couselo , Javier Cortés , Maurizio Scaltriti
Seminars in Oncology 41 ( 5) 576 -588
4
2014
Synergy between trastuzumab and pertuzumab for human epidermal growth factor 2 (Her2) from colocalization: an in silicobased mechanism
Gloria Fuentes , Maurizio Scaltriti , José Baselga , Chandra S Verma
Breast Cancer Research 13 ( 3) 1 -9
50
2011
Abstract P1-17-02: Adaptive and acquired mechanisms of resistance to PI3K inhibitors
Sarat Chandarlapaty , Maurizio Scaltriti , Marie Will , Zhiqiang Li
Cancer Research 75
2015
Abstract P4-11-29: Quantitative measurement of HER2 levels by multiplexed mass spectrometry from FFPE tissue predicts survival in patients treated with anti-HER2 based therapy
Paolo Nuciforo , Sheeno Thyparambil , Claudia Aura , Ana Garrido-Castro
Cancer Research 75
2015
Genotyping tumour DNA in cerebrospinal fluid and plasma of a HER2-positive breast cancer patient with brain metastases
Giulia Siravegna , Elena Geuna , Benedetta Mussolin , Giovanni Crisafulli
ESMO Open 2 ( 4)
34
2017
Violeta Serra, PhD Neal Rosen Saverio Bettuzzi Pau Castel Pedram Razavi Moshe Elkabets Paolo Nuciforo David M Hyman Pieter Eichhorn David Solit Maura Dickler Chandra Verma Federico Rojo Celina Garcia-Garcia Yosi Shamay Charles Rudin Filippo Montemurro Christina Leslie Poulikos I. Poulikakos Michael F Berger