引用次数
引用: 5,856
H-指数: 42
I10-指数 : 65
出版物: 126
Analysis of the Evolutionary Forces in an Immunodominant CD8 Epitope in Hepatitis C Virus at a Population Level
Christoph Neumann-Haefelin , David N. Frick , Jing Jing Wang , Oliver G. Pybus
Journal of Virology 82 ( 7) 3438 -3451
59
2008
Fluorescent primuline derivatives inhibit hepatitis C virus NS3-catalyzed RNA unwinding, peptide hydrolysis and viral replicase formation.
Jean Ndjomou , Rajesh Kolli , Sourav Mukherjee , William R. Shadrick
Antiviral Research 96 ( 2) 245 -255
15
2012
Development of novel therapies for hepatitis C.
Stanley M. Lemon , Jane A. McKeating , Thomas Pietschmann , David N. Frick
Antiviral Research 86 ( 1) 79 -92
77
2010
NMR studies of the conformations and location of nucleotides bound to the Escherichia coli MutT enzyme.
David N. Frick , David J. Weber , Chitrananda Abeygunawardana , Apostolos G. Gittis
Biochemistry 34 ( 16) 5577 -5586
27
1995
Molecular Basis for ADP-Ribose Binding to the Mac1 Domain of SARS-CoV-2 nsp3.
David N. Frick , Rajdeep S. Virdi , Nemanja Vuksanovic , Narayan Dahal
Biochemistry 59 ( 28) 2608 -2615
38
2020
Discovery of Drug-like Ligands for the Mac1 Domain of SARS-CoV-2 Nsp3
Rajdeep S. Virdi , Robert V. Bavisotto , Nicholas C. Hopper , Nemanja Vuksanovic
SLAS DISCOVERY: Advancing the Science of Drug Discovery 25 ( 10) 1162 -1170
26
2020
Shape-based virtual screening, synthesis and evaluation of novel pyrrolone derivatives as antiviral agents against HCV.
Marcella Bassetto , Pieter Leyssen , Johan Neyts , Mark M. Yerukhimovich
Bioorganic & Medicinal Chemistry Letters 27 ( 4) 936 -940
4
2017
Monitoring helicase activity with molecular beacons.
Craig A. Belon , David N. Frick
BioTechniques 45 ( 4) 433 -442
48
2008
A Complex of the Bacteriophage T7 Primase-Helicase and DNA Polymerase Directs Primer Utilization
Masato Kato , David N Frick , Joonsoo Lee , Stanley Tabor
Journal of Biological Chemistry 276 ( 24) 21809 -21820
33
2001
Orf186 represents a new member of the nudix hydrolases, active on adenosine(5)triphospho(5)adenosine, ADP-ribose, and NADH
Suzanne F. O’Handley , David N. Frick , Christopher A. Dunn , Maurice J. Bessman
Journal of Biological Chemistry 273 ( 6) 3192 -3197
70
1998
Simultaneously Targeting the NS3 Protease and Helicase Activities for More Effective Hepatitis C Virus Therapy
Jean Ndjomou , M. Josie Corby , Noreena L. Sweeney , Alicia M. Hanson
ACS Chemical Biology 10 ( 8) 1887 -1896
7
2015
Identification and Analysis of Inhibitors Targeting the Hepatitis C Virus NS3 Helicase
Alicia M. Hanson , John J. Hernandez , William R. Shadrick , David N. Frick
Methods in Enzymology 511 463 -483
18
2012
Analysis of the Enzymatic Activity of an NS3 Helicase Genotype 3a Variant Sequence Obtained from a Relapse Patient
Paola J. S. Provazzi , Sourav Mukherjee , Alicia M. Hanson , Mauricio L. Nogueira
PLOS ONE 10 ( 12) e0144638
2
2015
Hepatitis C Virus Subgenomic Replicon Requires an Active NS3 RNA Helicase
Angela M. I. Lam , David N. Frick
Journal of Virology 80 ( 1) 404 -411
166
2006
Aurintricarboxylic acid modulates the affinity of hepatitis C virus NS3 helicase for both nucleic acid and ATP.
William R. Shadrick , Sourav Mukherjee , Alicia M. Hanson , Noreena L. Sweeney
Biochemistry 52 ( 36) 6151 -6159
2013
Two Novel Conserved Motifs in the Hepatitis C Virus NS3 Protein Critical for Helicase Action
Angela M. I. Lam , David Keeney , David N. Frick
Journal of Biological Chemistry 278 ( 45) 44514 -44524
54
2003
Characterization of a Novel DNA Primase from the Salmonella typhimurium Bacteriophage SP6
Timothy Y. Tseng , David N. Frick , Charles C. Richardson
Biochemistry 39 ( 7) 1643 -1654
14
2000
Primuline Derivatives That Mimic RNA to Stimulate Hepatitis C Virus NS3 Helicase-catalyzed ATP Hydrolysis *
Noreena L. Sweeney , William R. Shadrick , Sourav Mukherjee , Kelin Li
Journal of Biological Chemistry 288 ( 27) 19949 -19957
12
2013
PSI-7851, a Pronucleotide of β-d-2′-Deoxy-2′-Fluoro-2′-C-Methyluridine Monophosphate, Is a Potent and Pan-Genotype Inhibitor of Hepatitis C Virus Replication
Angela M. Lam , Eisuke Murakami , Christine Espiritu , Holly M. Micolochick Steuer
Antimicrobial Agents and Chemotherapy 54 ( 8) 3187 -3196
126
2010
Cloning, purification, and properties of a novel NADH pyrophosphatase. Evidence for a nucleotide pyrophosphatase catalytic domain in MutT-like enzymes.
David N. Frick , Maurice J. Bessman
Journal of Biological Chemistry 270 ( 4) 1529 -1534
84
1995
Angela Lam Alicia Hanson Suzanne O'Handley Sourav Mukherjee, PhD Jean Ndjomou Frank Schoenen David J. Weber Johan Neyts Kevin Frankowski Christopher A Dunn Andrea Brancale Marcella Bassetto Marietta Lee Nicholas R. Silvaggi Raicu Group Calender Anne-Frances Miller Michael Sofia Martino Bolognesi Mario Milani