SAR of 4-hydroxypiperidine and hydroxyalkyl substituted heterocycles as novel p38 map kinase inhibitors.
Laszlo Revesz , Franco E Di Padova , Thomas Buhl , Roland Feifel
Bioorganic & Medicinal Chemistry Letters 10 ( 11) 1261 -1264
69
2000
Optimizing Metabolic Stability via Soft Spot Identification (SSID)
Markus Trunzer , Alfred G Zimmerlin , Bernard Faller
Synthesis of dehydrogenation polymers of ferulic acid with high specificity by a purified cell-wall peroxidase from French bean (Phaseolus vulgaris L.).
A Zimmerlin , P Wojtaszek , G P Bolwell
Biochemical Journal 299 ( 3) 747 -753
52
1994
Screening for a drug interaction of FTY720 on cyclosporine in renal transplant patients
JM Kovarik , A Skerjanec , A Zimmerlin
Am. J. Trans 3 483 -483
3
2003
Preclinical activity of AEE788, a potent new inhibitor of the ErbB and VEGF receptor tyrosine kinases. Discovery and in vitro profile of AEE788.
G Caravatti , G Bold , J Bruggen , P Furet
CLINICAL CANCER RESEARCH 9 ( 16) 6098S -6098S
2
2003
Optimized expression of a wheat obtusifoliol 14 alpha-demethylase (CYP51) in yeast
M Taton , F Cabello-Hurtado , A Zimmerlin , S Bak
FASEB JOURNAL 11 ( 9) A812 -A812
1997
Multiple xenobiotic‐inducible P450s are involved in alkoxycoumarin and alkoxyresorufin metabolism in higher plants
Y Batard , A Zimmerlin , M Le Ret , F Durst
Plant Cell and Environment 18 ( 5) 523 -533
14
1995
Xenobiotic-inducible alkoxycoumarin and alkoxyresorufin dealkylases in higher plants
Y Batard , A Zimmerlin , M Schalk , F Durst
Annales ANPP (France)
1995
DICLOFOP HYDROXYLASE-SPECIFICITY AND PHYSIOLOGICAL-ACTIVITY
A ZIMMERLIN , F DURST
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 204 12 -AGRO
1992
Dna Damage Inhibitors
Grazyna Wieczorek Hildesheim , Sascha Gutmann , Clemens Scheufler , Alexandra Hinniger
R. Mah, M. Gerspacher, A. von Sprecher, S. Stutz, V. Tschinke, GP Anderson, C. Bertrand, N. Subramanian and
HA Ball , M Itoh , J Kuwahara , K Itoh
Bioorganic & Medicinal Chemistry Letters 12 ( 16)
Apoptosis-Inducing Activity of Synthetic Intermediates of Halichlorine,
HA Ball , M Itoh , J Kuwahara , K Itoh
Bioorganic & Medicinal Chemistry Letters 12 ( 16) 2069 -2072
17
2002
BET bromodomain inhibitors regulate keratinocyte plasticity.
Sebastian Bergling , Vito Guagnano , Laure Bouchez , Alfred Zimmerlin
Nature Chemical Biology 17 ( 3) 280 -290
1
2021
Aryl hydroxylation of the herbicide diclofop by a wheat cytochrome p-450 monooxygenase : substrate specificity and physiological activity.
Alfred Zimmerlin , Francis Durst
Plant Physiology 100 ( 2) 874 -881
77
1992
Cytochrome P-450-Dependent Hydroxylation of Lauric Acid at the Subterminal Position and Oxidation of Unsaturated Analogs in Wheat Microsomes
Alfred Zimmerlin , Jean-Pierre Salaün , Francis Durst , Charles Mioskowski
Plant Physiology 100 ( 2) 868 -873
35
1992
Discovery of 3-(2,6-Dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), A Potent and Selective Inhibitor of the Fibroblast Growth Factor Receptor Family of Receptor Tyrosine Kinase
Vito Guagnano , Pascal Furet , Carsten Spanka , Vincent Bordas
Journal of Medicinal Chemistry 54 ( 20) 7066 -7083
435
2011
New Perspectives on Drug-Induced Liver Injury Risk Assessment of Acyl Glucuronides.
Markus Walles , Alan P. Brown , Alfred Zimmerlin , Peter End
Chemical Research in Toxicology 33 ( 7) 1551 -1560
12
2020
CYP4F Enzymes Are Responsible for the Elimination of Fingolimod (FTY720), a Novel Treatment of Relapsing Multiple Sclerosis
Yi Jin , Markus Zollinger , Hubert Borell , Alfred Zimmerlin
Drug Metabolism and Disposition 39 ( 2) 191 -198
42
2011
CYP3A Time-Dependent Inhibition Risk Assessment Validated with 400 Reference Drugs
Alfred Zimmerlin , Markus Trunzer , Bernard Faller
Drug Metabolism and Disposition 39 ( 6) 1039 -1046
53
2011
Design of Potent and Selective Covalent Inhibitors of Bruton’s Tyrosine Kinase Targeting an Inactive Conformation
Robert Pulz , Daniela Angst , Janet Dawson , Francois Gessier
ACS Medicinal Chemistry Letters 10 ( 10) 1467 -1472
12
2019