Xenobiotics: Substrates and inhibitors of the plant cytochrome P450
Michel Schalk , Marie-Agnès Pierrel , Alfred Zimmerlin , Yannick Batard
Environmental Science and Pollution Research 4 ( 4) 229 -234
13
1997
An Integrated Approach for Identification and Target Validation of Antifungal Compounds Active against Erg11p
Dominic Hoepfner , Shantanu Karkare , Stephen B. Helliwell , Martin Pfeifer
Antimicrobial Agents and Chemotherapy 56 ( 8) 4233 -4240
17
2012
Xenobiotic metabolism in plants: Aryl hydroxylation of diclofop by a cytochrome P-450 enzyme from wheat
Alfred Zimmerlin , Francis Durst
Phytochemistry 29 ( 6) 1729 -1732
39
1990
Cloning and functional expression in yeast of a cDNA coding for an obtusifoliol 14α-demethylase(CYP51) in wheat.
Francisco Cabello-Hurtado , Alfred Zimmerlin , Alain Rahier , Maryse Taton
Biochemical and Biophysical Research Communications 230 ( 2) 381 -385
31
1997
Plant cytochrome p450
G. Paul Bolwell , Kristin Bozak , Alfred Zimmerlin
Phytochemistry 37 ( 6) 1491 -1506
234
1994
Molecular identification and expression of the peroxidase responsible for the oxidative burst in French bean (Phaseolus vulgaris L.) and related members of the gene family.
Kristopher A. Blee , Steve C. Jupe , Gaelle Richard , Alfred Zimmerlin
Plant Molecular Biology 47 ( 5) 607 -620
120
2001
High-throughput in vitro profiling assays: lessons learnt from experiences at Novartis
Bernard Faller , Jianling Wang , Alfred Zimmerlin , Leslie Bell
Expert Opinion on Drug Metabolism & Toxicology 2 ( 6) 823 -833
24
2006
Tissue and subcellular immunolocalisation of enzymes of lignin synthesis in differentiating and wounded hypocotyl tissue of French bean (Phaseolus vulgaris L.)
ColinG. Smith , MatthewW. Rodgers , Alfred Zimmerlin , Dudley Ferdinando
Planta 192 ( 2) 155 -164
127
1994
Metabolic soft spot identification and compound optimization in early discovery phases using MetaSite and LC-MS/MS validation.
Markus Trunzer , Bernard Faller , Alfred Zimmerlin
Journal of Medicinal Chemistry 52 ( 2) 329 -335
83
2009
Fixing clearance as early as lead optimization using high throughput in vitro incubations in combination with exact mass detection and automatic structure elucidation of metabolites.
Alfred Zimmerlin , Michael Kiffe
Drug Discovery Today: Technologies 10 ( 1)
4
2013
The Origin of the Oxidative Burst in Plants
G. Paul Bolwell , Vernon S. Butt , Dewi R. Davies , Alfred Zimmerlin
Free Radical Research 23 ( 6) 517 -532
344
1995
Molecular cloning of the cDNA encoding a stress-inducible protein phosphatase 1 (PP1) catalytic subunit from French bean (Phaseolus vulgaris L.).
Alfred Zimmerlin , Steve C. Jupe , G. Paul Bolwell
Plant Molecular Biology 28 ( 3) 363 -368
10
1995
Discovery of LOU064 (Remibrutinib), a Potent and Highly Selective Covalent Inhibitor of Bruton's Tyrosine Kinase.
Daniela Angst , François Gessier , Philipp Janser , Anna Vulpetti
Journal of Medicinal Chemistry 63 ( 10) 5102 -5118
23
2020
Evaluation of Fluorescence-and Mass Spectrometry–Based CYP Inhibition Assays for Use in Drug Discovery
Leslie Bell , Shari Bickford , Phong Hung Nguyen , Jianling Wang
SLAS Discovery 13 ( 5) 343 -353
61
2008
Soft spot identification (SSID): a tool to identify next generation molecules
Phong Nguyen , Markus Trunzer , Alfred Zimmerlin , Sujal V Deshmukh
DRUG METABOLISM REVIEWS 48 122 -122
2016
EXPERIMENTAL VALIDATION OF SITE OF METABOLISM PREDICTION TO REDUCE METABOLIC CLEARANCE IN EARLY DISCOVERY
Alfred Zimmerlin , Markus Trunzer
DRUG METABOLISM REVIEWS 40 105 -105
2008
Mise en evidence et caracterisation de la monooxygenase a cytochrome p-450 du ble catalysant l'hydroxylation aromatique de l'herbicide diclofop: lien avec l'activite laurate hydroxylase
Alfred Zimmerlin
Université Louis Pasteur (Strasbourg)(1971-2008)
1991
Pimecrolimus: absorption, distribution, metabolism, and excretion in healthy volunteers after a single oral dose and supplementary investigations in vitro.
Markus Zollinger , Felix Waldmeier , Stefan Hartmann , Gerhard Zenke
Drug Metabolism and Disposition 34 ( 5) 765 -774
14
2006
SAR of 2,6-diamino-3,5-difluoropyridinyl substituted heterocycles as novel p38MAP kinase inhibitors.
Laszlo Revesz , Franco E. Di Padova , Thomas Buhl , Roland Feifel
Bioorganic & Medicinal Chemistry Letters 12 ( 16) 2109 -2112
84
2002
A locally active antiinflammatory macrolide (MLD987) for inhalation therapy of asthma.
Rene Hersperger , Karl-Heinz Buchheit , Salvatore Cammisuli , Albert Enz
Journal of Medicinal Chemistry 47 ( 20) 4950 -4957
13
2004