IQ consortium perspective: complementary LBA and LC–MS in protein therapeutics bioanalysis and biotransformation assessment
Surinder Kaur , Kevin P Bateman , Jim Glick , Mark Jairaj
Bioanalysis 12 ( 4) 257 -270
16
2020
Development and Application of Technology for Streamlining Top-Down Proteomics
John Fielding Kellie
Northwestern University
1
2012
Intact protein LC–MS for pharmacokinetics
John F Kellie
International Journal of Pharmacokinetics 4 ( 4)
2019
Application of high-resolution MS for development of peptide and large-molecule drug candidates
John F Kellie , Jonathan R Kehler , Matthew E Szapacs
Bioanalysis 8 ( 3) 169 -177
19
2016
A new era for proteomics
John F Kellie , Timothy W Sikorski , Bo An , Zhuo Chen
Bioanalysis 11 ( 19) 1731 -1735
1
2019
Native high-resolution mass spectrometry analysis of noncovalent protein complexes up to 450 kDa.
Zhuo Chen , John F Kellie , Charles S Hottenstein , Matthew E Szapacs
Bioanalysis 12 ( 19) 1353 -1362
1
2020
Intact mAb LC-MS for drug concentration from pre-clinical studies: bioanalytical method performance and in-life samples.
John F Kellie , Yun W Alelyunas , Josh Albert , Nicole A Schneck
Bioanalysis 12 ( 19) 1389 -1403
1
2020
A whole-molecule immunocapture LC–MS approach for the in vivo quantitation of biotherapeutics
John F Kellie , Jonathan R Kehler , Thomas J Mencken , Richard J Snell
Bioanalysis 8 ( 20) 2103 -2114
22
2016
Toward best practices in data processing and analysis for intact biotherapeutics by MS in quantitative bioanalysis.
John F Kellie , Jonathan R Kehler , Molly Z Karlinsey , Scott G Summerfield
Bioanalysis 9 ( 23) 1883 -1893
12
2017
Drug monitoring by volumetric absorptive microsampling: method development considerations to mitigate hematocrit effects
Kasie Fang , Chester L Bowen , John F Kellie , Molly Z Karlinsey
Bioanalysis 10 ( 4) 241 -255
27
2018
Review of approaches and examples for monitoring biotransformation in protein and peptide therapeutics by MS.
John F Kellie , Molly Z Karlinsey
Bioanalysis 10 ( 22) 1877 -1890
9
2018
Top-Down Characterization and Intact Mass Quantitation of a Monoclonal Antibody Drug from Serum by Use of a Quadrupole TOF MS System Equipped with Electron-Activated Dissociation
John F Kellie , Nicole A Schneck , Jason C Causon , Takashi Baba
Journal of the American Society for Mass Spectrometry 34 ( 1) 17 -26
2022
An antibody-free platform for multiplexed, sensitive quantification of protein biomarkers in complex biomatrices
Bo An , Timothy W Sikorski , John F Kellie , Zhuo Chen
Journal of Chromatography A 1676 463261 -463261
3
2022
A High Throughput Antibody-Free Platform for Multiplexed, Sensitive Quantification of Protein Biomarkers in Complex Biomatrices
Bo An , Timothy Sikorsiki , John F Kellie , Zhuo Chen
Sensitive Quantification of Protein Biomarkers in Complex Biomatrices
2021 White Paper on Recent Issues in Bioanalysis: Mass Spec of Proteins, Extracellular Vesicles, CRISPR, Chiral Assays, Oligos; Nanomedicines Bioanalysis; ICH M10 Section 7.1; Non-Liquid & Rare Matrices; Regulatory Inputs (Part 1A–Recommendations on Endogenous Compounds, Small Molecules, Complex Methods, Regulated Mass Spec of Large Molecules, Small Molecule, PoC & Part 1B-Regulatory Agencies' Inputs on Bioanalysis, Biomarkers, Immunogenicity, Gene & Cell Therapy and Vaccine)
Surinder Kaur , Stephen C Alley , Matt Szapacs , Amanda Wilson
Bioanalysis 14 ( 9) 505 -580
20
2022
Separation techniques for intact antibody analysis by mass spectrometry
Nicole A Schneck , Kshitij Khatri , Matthew D Maust , Mark E Jennings
Journal of Liquid Chromatography & Related Technologies 45 ( 17-20) 271 -283
1
2022
Quantitative measurement of intact alpha-synuclein proteoforms from post-mortem control and Parkinson's disease brain tissue by intact protein mass spectrometry
John F Kellie , Richard E Higgs , John W Ryder , Anthony Major
Scientific reports 4 ( 1) 5797 -5797
168
2014
The emerging process of Top Down mass spectrometry for protein analysis: biomarkers, protein-therapeutics, and achieving high throughput
John F Kellie , John C Tran , Ji Eun Lee , Dorothy R Ahlf
Molecular BioSystems 6 ( 9) 1532 -1539
121
2010
Determination of label efficiency and label degree of critical reagents by LC-MS and native MS
Katie Carle , John F Kellie , George R Gunn , Yong Jiang
Analytical Biochemistry 664 115033 -115033
4
2023
Protein LC-MS Tools for the Next Generation of Biotherapeutic Analyses from Preclinical and Clinical Serum
Nicole A Schneck , John T Mehl , John F Kellie
Journal of the American Society for Mass Spectrometry 34 ( 9) 1837 -1846
2023