Overcoming ABCG2-mediated drug resistance with imidazo-[1,2-b]-pyridazine-based Pim1 kinase inhibitors.
Richard A. J. Darby , Amanda Unsworth , Stefan Knapp , Ian D. Kerr
Cancer Chemotherapy and Pharmacology 76 ( 4) 853 -864
5
2015
Accumulation and distribution of doxorubicin in tumour spheroids: the influence of acidity and expression of P-glycoprotein.
Howard R. Mellor , Richard Callaghan
Cancer Chemotherapy and Pharmacology 68 ( 5) 1179 -1190
27
2011
Hepatic enzyme activity is the major factor determining elimination rate of high-clearance drugs in cirrhosis
Richard Callaghan , Paul V. Desmond , Phillip Paull , Maurice L. Mashfor
Hepatology 18 ( 1) 54 -60
14
1993
Factors affecting the hepatic elimination of oxidized and of glucoronidated high clearance drugs following acute administration of carbon tetrachloride
Richard Callaghan , Phillip Paull , Paul V. Desmond , Maurice L. Mashford
Journal of Hepatology 20 ( 6) 742 -749
2
1994
Front Cover: A Novel Class of N‐Sulfonyl and N‐Sulfamoyl Noscapine Derivatives that Promote Mitotic Arrest in Cancer Cells (ChemMedChem 23/2019)
Cassandra Yong , Shane M. Devine , Xuexin Gao , Angelina Yan
ChemMedChem 14 ( 23) 1950 -1950
2019
The molecular interaction of the high affinity reversal agent XR9576 with P-glycoprotein
Catherine Martin , Georgina Berridge , Prakash Mistry , Christopher Higgins
British Journal of Pharmacology 128 ( 2) 403 -411
227
1999
The multi‐drug resistance reversal agent SR33557 and modulation of vinca alkaloid binding to P‐glycoprotein by an allosteric interaction
Catherine Martin , Georgina Berridge , Christopher F. Higgins , Richard Callaghan
British Journal of Pharmacology 122 ( 4) 765 -771
76
1997
Collateral sensitivity as a strategy against cancer multidrug resistance.
Kristen M. Pluchino , Matthew D. Hall , Andrew S. Goldsborough , Richard Callaghan
Drug Resistance Updates 15 ( 1) 98 -105
303
2012
Resistance to chemotherapy in cancer: a complex and integrated cellular response.
Howard R. Mellor , Richard Callaghan
Pharmacology 81 ( 4) 275 -300
196
2008
Dual effects of the PI3K inhibitor ZSTK474 on multidrug efflux pumps in resistant cancer cells.
Divya Muthiah , Richard Callaghan
European Journal of Pharmacology 815 127 -137
4
2017
The ABC Transporters: Structural Insights into Drug Transport
Robert C. Ford , Alhaji B. Kamis , Ian D. Kerr , Richard Callaghan
Transporters as Drug Carriers 1 -48
6
2009
Improving the stability and function of purified ABCB1 and ABCA4: The influence of membrane lipids
Naomi L. Pollock , Christopher A. McDevitt , Richard Collins , Petronella H.M. Niesten
Biochimica et Biophysica Acta 1838 ( 1) 134 -147
22
2014
Inhibition of the Multidrug Resistance P-Glycoprotein: Time for a Change of Strategy?
Richard Callaghan , Frederick Luk , Mary Bebawy
Drug Metabolism and Disposition 42 ( 4) 623 -631
203
2014
Overcoming P-Glycoprotein-Mediated Drug Resistance with Noscapine Derivatives.
Divya Muthiah , Georgia K. Henshaw , Aaron J. DeBono , Ben Capuano
Drug Metabolism and Disposition 47 ( 2) 164 -172
7
2019
P-glycoprotein retains function when reconstituted into a sphingolipid- and cholesterol-rich environment
Szabolcs Modok , Catherine Heyward , Richard Callaghan
Journal of Lipid Research 45 ( 10) 1910 -1918
66
2004
The Binding of Auxin to the Arabidopsis Auxin Influx Transporter AUX1
David J. Carrier , Norliza Tendot Abu Bakar , Ranjan Swarup , Richard Callaghan
Plant Physiology 148 ( 1) 529 -535
53
2008
The Effects of Severe Hypoxia on Glycolytic Flux and Enzyme Activity in a Model of Solid Tumors.
Hannah Smith , Mary Board , Andrea Pellagatti , Helen Turley
Journal of Cellular Biochemistry 117 ( 8) 1890 -1901
13
2016
Protein Kinase C-mediated Phosphorylation Does Not Regulate Drug Transport by the Human Multidrug Resistance P-glycoprotein
Hugh R. Goodfellow , Alessandro Sardini , Stephan Ruetz , Richard Callaghan
Journal of Biological Chemistry 271 ( 23) 13668 -13674
111
1996
The functional purification of P-glycoprotein is dependent on maintenance of a lipid–protein interface
Richard Callaghan , Georgina Berridge , David R Ferry , Christopher F Higgins
Biochimica et Biophysica Acta 1328 ( 2) 109 -124
93
1997
The importance of cholesterol in maintenance of P-glycoprotein activity and its membrane perturbing influence.
Alice Rothnie , Daniel Theron , Loredana Soceneantu , Catherine Martin
European Biophysics Journal 30 ( 6) 430 -442
106
2001