Aloke K Dutta
机构: Professor, wayne state university
每年引用次数
引用次数
引用: 3,637
H-指数: 37
I10-指数 : 99
出版物: 284
Interaction between a hydroxypiperidine analogue of 4-(2-benzhydryloxy-ethyl)-1-(4-fluorobenzyl)piperidine and Aspartate 68 in the human dopamine transporter
Juan Zhen , Soumen Maiti , Nianhang Chen , Aloke K. Dutta
European Journal of Pharmacology 506 ( 1) 17 -26
12
2004
Dual incorporation of photoaffinity ligands on dopamine transporters implicates proximity of labeled domains.
Roxanne A. Vaughan , Jon D. Gaffaney , John R. Lever , Maarten E. A. Reith
Molecular Pharmacology 59 ( 5) 1157 -1164
24
2001
O-526, a piperidine analog of GBR 12909, retains high affinity for the dopamine transporter in monkey caudate-putamen
Bertha K. Madras , Maarten E.A. Reith , Peter C. Meltzer , Aloke K. Dutta
European Journal of Pharmacology 267 ( 2) 167 -173
10
1994
Efficacy of Hybrid Tetrahydrobenzo[d]thiazole Based Aryl Piperazines D-264 and D-301 at D2 and D3 Receptors
Juan Zhen , Tamara Antonio , Joanna C. Jacob , David K. Grandy
Neurochemical Research 41 ( 1) 328 -339
3
2016
Three-dimensional quantitative structure-activity relationship (3D QSAR) and pharmacophore elucidation of tetrahydropyran derivatives as serotonin and norepinephrine transporter inhibitors.
Prashant S. Kharkar , Maarten E. A. Reith , Aloke K. Dutta
Journal of Computer-aided Molecular Design 22 ( 1) 1 -17
11
2008
Inhibition of alpha-synuclein aggregation by multifunctional dopamine agonists assessed by a novel in vitro assay and an in vivo Drosophila synucleinopathy model
Deepthi Yedlapudi , Gnanada S. Joshi , Dan Luo , Sokol V. Todi
Scientific Reports 6 ( 1) 38510 -38510
35
2016
Investigation of various N-heterocyclic substituted piperazine versions of 5/7-{[2-(4-aryl-piperazin-1-yl)-ethyl]-propyl-amino}-5,6,7,8-tetrahydro-naphthalen-2-ol: effect on affinity and selectivity for dopamine D3 receptor.
Dennis A. Brown , Manoj Mishra , Suhong Zhang , Swati Biswas
Bioorganic & Medicinal Chemistry 17 ( 11) 3923 -3933
22
2009
Discovery of novel trisubstituted asymmetric derivatives of (2S,4R,5R)-2-benzhydryl-5-benzylaminotetrahydropyran-4-ol, exhibiting high affinity for serotonin and norepinephrine transporters in a stereospecific manner.
Shijun Zhang , Juan Zhen , Maarten E. A. Reith , Aloke K. Dutta
Journal of Medicinal Chemistry 48 ( 15) 4962 -4971
30
2005
High affinity hydroxypiperidine analogues of 4-(2-benzhydryloxyethyl)-1-(4-fluorobenzyl)piperidine for the dopamine transporter: stereospecific interactions in vitro and in vivo.
Sujit K. Ghorai , Charles Cook , Matthew Davis , Sylesh K. Venkataraman
Journal of Medicinal Chemistry 46 ( 7) 1220 -1228
39
2003
Interaction of cis-(6-Benzhydrylpiperidin-3-yl)benzylamine Analogues with Monoamine Transporters: Structure−Activity Relationship Study of Structurally Constrained 3,6-Disubstituted Piperidine Analogues of (2,2-Diphenylethyl)-[1-(4-fluorobenzyl)piperidin-4-ylmethyl]amine
Rohit B. Kolhatkar , Sujit K. Ghorai , Clifford George , Maarten E. A. Reith
Journal of Medicinal Chemistry 46 ( 11) 2205 -2215
21
2003
Further structurally constrained analogues of cis-(6-benzhydrylpiperidin-3-yl)benzylamine with elucidation of bioactive conformation: discovery of 1,4-diazabicyclo[3.3.1]nonane derivatives and evaluation of their biological properties for the monoamine transporters.
Rohit Kolhatkar , Charles D. Cook , Sujit K. Ghorai , Jeffrey Deschamps
Journal of Medicinal Chemistry 47 ( 21) 5101 -5113
14
2004
Further structural exploration of trisubstituted asymmetric pyran derivatives (2S,4R,5R)-2-benzhydryl-5-benzylamino-tetrahydropyran-4-ol and their corresponding disubstituted (3S,6S) pyran derivatives: a proposed pharmacophore model for high-affinity interaction with the dopamine, serotonin, and norepinephrine transporters.
Shijun Zhang , Fernando Fernandez , Stuart Hazeldine , Jeffrey Deschamps
Journal of Medicinal Chemistry 49 ( 14) 4239 -4247
26
2006
Development of (S)-N6-(2-(4-(Isoquinolin-1-yl)piperazin-1-yl)ethyl)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]-thiazole-2,6-diamine and its analogue as a D3 receptor preferring agonist: Potent in vivo activity in Parkinson’s disease animal models
Balaram Ghosh , Tamara Antonio , Juan Zhen , Prashant Kharkar
Journal of Medicinal Chemistry 53 ( 3) 1023 -1037
44
2010
Discovery of 4-(4-(2-((5-Hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl)(propyl)amino)ethyl)piperazin-1-yl)quinolin-8-ol and its analogues as highly potent dopamine D2/D3 agonists and as iron chelator: in vivo activity indicates potential application in symptomatic and neuroprotective therapy for Parkinson's disease.
Balaram Ghosh , Tamara Antonio , Maarten E. A. Reith , Aloke K. Dutta
Journal of Medicinal Chemistry 53 ( 5) 2114 -2125
52
2010
Structure−Activity Relationship Studies of Novel 4-[2-[Bis(4-fluorophenyl)methoxy]ethyl]-1-(3-phenylpropyl)piperidine Analogs: Synthesis and Biological Evaluation at the Dopamine and Serotonin Transporter Sites
Aloke K. Dutta , Cen Xu , Maarten E. A. Reith
Journal of Medicinal Chemistry 39 ( 3) 749 -756
45
1996
Structurally constrained hybrid derivatives containing octahydrobenzo[g or f]quinoline moieties for dopamine D2 and D3 receptors: Binding characterization at D2/D3 receptors and elucidation of a pharmacophore model
Dennis A. Brown , Prashant S. Kharkar , Ingrid Parrington , Maarten E. A. Reith
Journal of Medicinal Chemistry 51 ( 24) 7806 -7819
22
2008
Highly Selective, Novel Analogs of 4-[2-(Diphenylmethoxy)ethyl]- 1-benzylpiperidine for the Dopamine Transporter: Effect of Different Aromatic Substitutions on Their Affinity and Selectivity
Aloke K. Dutta , Lori L. Coffey , Maarten E. A. Reith
Journal of Medicinal Chemistry 40 ( 1) 35 -43
33
1997
Expansion of Structure−Activity Studies of Piperidine Analogues of 1-[2-(Diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine (GBR 12935) Compounds by Altering Substitutions in the N-Benzyl Moiety and Behavioral Pharmacology of Selected Molecules
Aloke K. Dutta , Matthew C. Davis , Xiang-Shu Fei , Patrick M. Beardsley
Journal of Medicinal Chemistry 45 ( 3) 654 -662
13
2002
Lipophilic amino alcohols with calcium channel blocking activity.
Anil S. Sipahimalani , John L. Werth , Robert H. Michelson , Aloke K. Dutta
Biochemical Pharmacology 44 ( 10) 2039 -2046
9
1992
An improved asymmetric synthetic route to a novel triple uptake inhibitor antidepressant (2S,4R,5R)-2-benzhydryl-5-((4-methoxybenzyl)amino)tetrahydro-2H-pyran-4-ol (D-142).
Bhaskar Gopishetty , Sanjib Gogoi , Aloke K. Dutta
Tetrahedron-asymmetry 22 ( 10) 1081 -1086
12
2011