PGC-1α regulates mitochondrial calcium homeostasis, SR stress and cell death to mitigate skeletal muscle aging
Jonathan F. Gill , Julien Delezie , Gesa Santos , Shawn McGuirk
bioRxiv 451229
2018
Inhibition of DNMT1 and ERRα crosstalk suppresses breast cancer via derepression of IRF4.
Mathieu Vernier , Shawn McGuirk , Catherine R. Dufour , Liangxinyi Wan
Oncogene 39 ( 41) 6406 -6420
20
2020
Estrogen-related receptors are targetable ROS sensors
Mathieu Vernier , Catherine R. Dufour , Shawn McGuirk , Charlotte Scholtes
Genes & Development 34 544 -559
49
2020
PGC-1α Promotes Breast Cancer Metastasis and Confers Bioenergetic Flexibility against Metabolic Drugs
Sylvia Andrzejewski , Eva Klimcakova , Radia M. Johnson , Sébastien Tabariès
Cell Metabolism 26 ( 5) 778 -787.e5
90
2017
mTOR Controls Mitochondrial Dynamics and Cell Survival via MTFP1
Masahiro Morita , Julien Prudent , Kaustuv Basu , Vanessa Goyon
Molecular Cell 67 ( 6) 922
237
2017
Altered mitochondrial fusion drives defensive glutathione synthesis in cells able to switch to glycolytic ATP production.
David A. Patten , Shawn McGuirk , Ujval Anilkumar , Ghadi Antoun
Biochimica et Biophysica Acta 1868 ( 1) 118854 -118854
2
2021
Metabolic Fitness and Plasticity in Cancer Progression
Shawn McGuirk , Yannick Audet-Delage , Julie St-Pierre
Trends in cancer 6 ( 1) 49 -61
24
2020
Androgen-Dependent Repression of ERRγ Reprograms Metabolism in Prostate Cancer.
Étienne Audet-Walsh , Tracey Yee , Shawn McGuirk , Mathieu Vernier
Cancer Research 77 ( 2) 378 -389
26
2017
Interplay between ShcA Signaling and PGC-1α Triggers Targetable Metabolic Vulnerabilities in Breast Cancer.
Young Kyuen Im , Ouafa Najyb , Simon-Pierre Gravel , Shawn McGuirk
Cancer Research 78 ( 17) 4826 -4838
6
2018
PGC-1α supports glutamine metabolism in breast cancer.
Shawn McGuirk , Simon-Pierre Gravel , Geneviève Deblois , David J Papadopoli
Cancer and Metabolism 1 ( 1) 22 -22
153
2013
PGC-1α Promotes the Growth of ErbB2/Neu–Induced Mammary Tumors by Regulating Nutrient Supply
Eva Klimcakova , Valérie Chénard , Shawn McGuirk , David Germain
Cancer Research 72 ( 6) 1538 -1546
41
2012
Peroxisome proliferator‐activated receptor γ coactivator 1α regulates mitochondrial calcium homeostasis, sarcoplasmic reticulum stress, and cell death to mitigate skeletal muscle aging
Jonathan F. Gill , Julien Delezie , Gesa Santos , Shawn McGuirk
Aging Cell 18 ( 5)
8
2019
Morphological and functional remodelling of the neuromuscular junction by skeletal muscle PGC-1α
Anne-Sophie Arnold , Jonathan Gill , Martine Christe , Rocío Ruiz
Nature Communications 5 ( 1) 3569 -3569
43
2014
HSP90 inhibitors induce GPNMB cell-surface expression by modulating lysosomal positioning and sensitize breast cancer cells to glembatumumab vedotin
Marco Biondini , Alex Kiepas , Leeanna El-Houjeiri , Matthew G Annis
Oncogene 41 ( 12) 1701 -1717
13
2022
The Frontiers of DNA Regulation: Developing a National Policy Framework Encouraging Transparency, Security, and Cost-efficiency of Genetic Technology and Data
Shawn McGuirk , Stefanie Sultmanis , Alana R Westwood , Kathlyn N Woolfson
Journal of Science Policy and Governance 16 1 -1
2020
Resistance to different anthracycline chemotherapeutics elicits distinct and actionable primary metabolic dependencies in breast cancer
Shawn McGuirk , Yannick Audet-Delage , Matthew G Annis , Yibo Xue
Elife 10 e65150 -e65150
35
2021
PGC-1α regulates mitochondrial-sarcoplasmic reticulum (SR)-mediated calcium exchange, SR stress and cell death to mitigate skeletal muscle aging
Jonathan Gill , Julien Delezie , Shawn McGuirk , Svenia Schnyder
Aging cell
2019
Spatiotemporal modeling of chemoresistance evolution in breast tumors uncovers dependencies on SLC38A7 and SLC46A1
Yannick Audet-Delage , Catherine St-Louis , Lucía Minarrieta , Shawn McGuirk
Cell Reports 42 ( 10)
3
2023
PGC-1s shape epidermal physiology by modulating keratinocyte proliferation and terminal differentiation
Simon-Pierre Gravel , Youcef Ben Khalifa , Shawn McGuirk , Catherine St-Louis
Iscience 26 ( 4)
5
2023
Student perspective of STEM education in Canada
Chelsea Cavanagh , Liam Crapper , Karolin Dietrich , Tina Gruosso
https://www.sp-exchange.ca/reports
2016
Vincent Giguere Étienne Audet-Walsh Christoph Handschin ivan topisirovic Simon-Pierre Gravel Heidi M. McBride Masahiro Morita Ola Larsson Kaustuv Basu Stefan Strack John Bergeron Nahum Sonenberg Nadeem Siddiqui Brandon Faubert Russell G Jones Karsten Hiller Genevieve Deblois Rocío Ruiz Lucia Tabares William J. Muller