引用次数
引用: 42,469
H-指数: 105
I10-指数 : 219
出版物: 386
Small-molecule hydrophobic tagging–induced degradation of HaloTag fusion proteins
Taavi K Neklesa , Hyun Seop Tae , Ashley R Schneekloth , Michael J Stulberg
Nature Chemical Biology 7 ( 8) 538 -543
343
2011
Remembering where we are: Positional information in salamander limb regeneration.
Grant Parker Flowers , Craig M Crews
Developmental Dynamics 249 ( 4) 465 -482
1
2020
Targeted protein destabilization reveals an estrogen-mediated ER stress response
Kanak Raina , Devin J Noblin , Yevgeniy V Serebrenik , Alison Adams
Nature Chemical Biology 10 ( 11) 957 -962
47
2014
Pharmacological targeting of the pseudokinase Her3
Ting Xie , Sang Min Lim , Kenneth D Westover , Michael E Dodge
Nature Chemical Biology 10 ( 12) 1006 -1012
101
2014
Lack of Proteasome Active Site Allostery as Revealed by Subunit-Specific Inhibitors
Jayhyuk Myung , Kyung Bo Kim , Kristina Lindsten , Nico P Dantuma
Molecular Cell 7 ( 2) 411 -420
134
2001
Protein degraders enter the clinic—a new approach to cancer therapy
Deborah Chirnomas , Keith R Hornberger , Craig M Crews
Nature Reviews Clinical Oncology 20 ( 4) 265 -278
2023
Targeted dephosphorylation of tau by phosphorylation targeting chimeras (PhosTACs) as a therapeutic modality
Zhenyi Hu , Po-Han Chen , Wenxue Li , Todd Douglas
Journal of the American Chemical Society 145 ( 7) 4045 -4055
2023
PROTAC targeted protein degraders: the past is prologue
Miklós Békés , David R Langley , Craig M Crews
Nature Reviews Drug Discovery 21 ( 3) 181 -200
327
2022
PROTACs: past, present and future
Ke Li , Craig M Crews
Chemical Society Reviews 51 ( 12) 5214 -5236
37
2022
ARV-110: an androgen receptor PROTAC degrader for prostate cancer
Taavi Neklesa , Lawrence B Snyder , Ryan R Willard , Nicholas Vitale
Cancer research 78 ( 13\_Supplement) 5236 -5236
30
2018
Recent developments in PROTAC-mediated protein degradation: from bench to clinic
Zhenyi Hu , Craig M Crews
ChemBioChem 23 ( 2) e202100270
60
2022
Regulated induced proximity targeting chimeras (RIPTACs): a novel heterobifunctional small molecule therapeutic strategy for killing cancer cells selectively
Kanak Raina , Chris D Forbes , Rebecca Stronk , Jonathan P Rappi Jr
bioRxiv
1
2023
Life mimics art
Muthukumaran Venkatachalapathy , Craig M Crews
Cell Research 33 ( 4) 267 -268
2023
The Advantages of Targeted Protein Degradation Over Inhibition: An RTK Case Study
George M Burslem , Blake E Smith , Ashton C Lai , Saul Jaime-Figueroa
Cell Chemical Biology 25 ( 1) 67 -77.e3
406
2018
Compounds and methods for the enhanced degradation of targeted proteins and other polypeptides by an E3 ubiquitin ligase
Craig M Crews , Dennis Buckley , Alessio Ciulli , William Jorgensen
156
2020
Compounds & Methods for the Enhanced Degradation of Targeted Proteins & Other Polypeptides by an E3 Ubiquitin Ligase
Craig M Crews , Dennis Buckley , Alessio Ciulli , William L Jorgensen
5
2019
Structure of Human Methionine Aminopeptidase-2 Complexed with Fumagillin
Shenping Liu , Joanne Widom , Christopher W Kemp , Craig M Crews
Science 282 ( 5392) 1324 -1327
514
1998
CELLULAR IMMUNOLOGY AND IMMUNE REGULATION-The Selective Proteasome Inhibitors Lactacystin and Epoxomicin Can Be Used to Either Up-or Down-Regulate Antigen Presentation at Nontoxic Doses
Katrin Schwarz , Rita de Giuli , Gunter Schmidtke , Susanne Kostka
Journal of Immunology 164 ( 12) 6147 -6157
2000
Mechanistic basis and efficacy of targeting the β-catenin–TCF7L2–JMJD6–c-Myc axis to overcome resistance to BET inhibitors
Dyana T Saenz , Warren Fiskus , Christopher P Mill , Dimuthu Perera
Blood, The Journal of the American Society of Hematology 135 ( 15) 1255 -1269
34
2020
Hydrophobically tagged small molecules as inducers of protein degradation
Nathanael Gray , Ting Xie , Sang Min Lim , Pasi A Janne
72
2017