Irina Bochkis
机构: Assistant Professor of Pharmacology, University of Virginia
主页: virginia.edu
每年引用次数
引用次数
引用: 834
H-指数: 11
I10-指数 : 11
出版物: 21
Bile acid-induced inflammatory signaling in mice lacking Foxa2 in the liver leads to activation of mTOR and age-onset obesity
Irina Mikhailovna Bochkis , Soona Shin , Klaus Hermann Kaestner
Molecular metabolism 2 ( 4) 447 -456
11
2013
Glucocorticoid Receptor-Dependent Gene Regulatory Networks
Phillip Phuc Le , Joshua R Friedman , Jonathan Schug , John E Brestelli
PLOS Genetics 1 ( 2) 159 -170
273
2005
Hepatocyte-specific ablation of Foxa2 alters bile acid homeostasis and results in endoplasmic reticulum stress
Irina M Bochkis , Nir E Rubins , Peter White , Emma E Furth
Nature Medicine 14 ( 8) 828 -836
188
2008
Changes in Nucleosome Occupancy Associated with Metabolic Alterations in Aged Mammalian Liver
Irina M Bochkis , Dariusz Przybylski , Jenny Chen , Aviv Regev
Cell Reports 9 ( 3) 996 -1006
45
2014
Targeting oxidized phospholipids by AAV-based gene therapy in mice with established hepatic steatosis prevents progression to fibrosis
Clint M Upchurch , Scott Yeudall , Caitlin M Pavelec , Dennis Merk
Science Advances 8 ( 28) eabn0050 -eabn0050
16
2022
Virus‐induced Hepatic Expression of an Oxidized Phospholipid‐binding Antibody Fragment Prevents Initiation of Hepatic Steatosis and Progression to Fibrosis
Clint M Upchurch , Scott Yeudall , Caitlin M Pavelec , Mohan Manjegowda
The FASEB Journal 36
2022
Redistribution of lamina-associated domains reshapes binding of pioneer factor FOXA2 in development of nonalcoholic fatty liver disease
Xiaolong Wei , Megan A Murphy , Nihal A Reddy , Yi Hao
Genome Research 32 ( 11-12) 1981 -1992
6
2022
Feeding desensitizes A1 adenosine receptors in adipose through FOXO1-mediated transcriptional regulation
Mitchell E Granade , Stefan R Hargett , Daniel S Lank , Michael C Lemke
Molecular Metabolism 63 101543 -101543
3
2022
Pioneer factor Foxa2 enables ligand-dependent activation of type II nuclear receptors FXR and LXRα
Jessica Kain , Xiaolong Wei , Nihal A Reddy , Andrew J Price
Molecular Metabolism 53 101291 -101291
14
2021
Pioneer Factor Foxa2 Mediates Chromatin Conformation Changes for Activation of Bile Acid Targets of FXR
Yi Hao , Lu Han , Anqi Wu , Irina M Bochkis
Cellular and Molecular Gastroenterology and Hepatology 17 ( 2) 237 -249
1
2024
Hepatic metabolic regulatory networks of Foxa2
Irina M Bochkis
University of Pennsylvania
2008
Pioneer factor Foxa2 enables ligand-dependent activation of LXRα
Jessica Kain , Xiaolong Wei , Andrew J. Price , Claire Woods
bioRxiv
2020
Genome-Wide Location Analysis Reveals Distinct Transcriptional Circuitry by Paralogous Regulators Foxa1 and Foxa2
Irina M. Bochkis , Jonathan Schug , Diana Z. Ye , Svitlana Kurinna
PLoS Genetics 8 ( 6) e1002770
50
2012
Impaired male fertility and atrophy of seminiferous tubules caused by haploinsufficiency for Foxa3
Rüdiger Behr , Sara D. Sackett , Irina M. Bochkis , Phillip Phuc Le
Developmental Biology 306 ( 2) 636 -645
28
2007
Foxa2-dependent hepatic gene regulatory networks depend on physiological state
Irina M. Bochkis , Jonathan Schug , Nir E. Rubins , Atul R. Chopra
Physiological Genomics 38 ( 2) 186 -195
18
2009
Changes at the nuclear lamina alter binding of pioneer factor Foxa2 in aged liver
Holly Whitton , Larry N. Singh , Marissa A. Patrick , Andrew J. Price
Aging Cell 17 ( 3) e12742
13
2018
Hdac3, Setdb1, and Kap1 mark H3K9me3/H3K14ac bivalent regions in young and aged liver.
Andrew J. Price , Mohan C. Manjegowda , Jessica Kain , Swetha Anandh
Aging Cell 19 ( 2)
6
2020
Pioneer factor Foxa2 mediates chromatin conformation changes in ligand-dependent activation of nuclear receptor FXR
Yi Hao , Lu Han , Anqi Wu , Irina Bochkis
bioRxiv 2023 -03
2023
AAV8-mediated expression of scFv-E06 to target oxidized phosphatidylcholines protects against hepatic fibrosis
Clint Upchurch , Scott Yeudall , Caitlin Pavelec , Dennis Merk
Free Radical Biology and Medicine 192 93 -93
2022
Reduced ZMPSTE24 expression leads to prelamin accumulation and development of steatosis in MASLD patients.
Anqi Wu , Joseph D Schinderle , Irina Bochkis
bioRxiv 2024.05. 16.594546 -2024.05. 16.594546
2024