Judith Straimer
机构: Novartis Institutes for BioMedical Researche
每年引用次数
引用次数
引用: 3,720
H-指数: 21
I10-指数 : 23
出版物: 34
K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates
J. Straimer , N. F. Gnadig , B. Witkowski , C. Amaratunga
Science 347 ( 6220) 428 -431
682
2015
The Plasmodium PI(4)K inhibitor KDU691 selectively inhibits dihydroartemisinin-pretreated Plasmodium falciparum ring-stage parasites.
L. Dembele , X. Ang , M. Chavchich , G. M. C. Bonamy
Scientific Reports 7 ( 1) 2325
24
2017
Studies on evolution of drug resistance in P. falciparum malaria in vivo and in vitro
Judith Straimer
2010
P. falciparum K13 mutations present varying degrees of artemisinin resistance and reduced fitness in African parasites
Frédéric Ariey , David A. Fidock , Rithea Leang , Judith Straimer
bioRxiv
2021
Artemisinin resistance phenotypes and K13 inheritance in a Plasmodium falciparum cross and Aotus model.
Juliana M. Sá , Sarah R. Kaslow , Michael A. Krause , Viviana A. Melendez-Muniz
Proceedings of the National Academy of Sciences of the United States of America 115 ( 49) 12513 -12518
30
2018
Site-specific genome editing in Plasmodium falciparum using engineered zinc-finger nucleases
Judith Straimer , Marcus C S Lee , Andrew H Lee , Bryan Zeitler
Nature Methods 9 ( 10) 993 -998
130
2012
Plasmodium falciparum K13 Mutations Differentially Impact Ozonide Susceptibility and Parasite Fitness In Vitro.
Judith Straimer , Nina F. Gnädig , Barbara H. Stokes , Michelle Ehrenberger
Mbio 8 ( 2) 1 -12
70
2017
Balancing drug resistance and growth rates via compensatory mutations in the Plasmodium falciparum chloroquine resistance transporter.
Ines Petersen , Stanislaw J. Gabryszewski , Geoffrey L. Johnston , Satish K. Dhingra
Molecular Microbiology 97 ( 2) 381 -395
36
2015
Artemisinin Action and Resistance in Plasmodium falciparum
Leann Tilley , Judith Straimer , Nina F. Gnädig , Stuart A. Ralph
Trends in Parasitology 32 ( 9) 682 -696
318
2016
In Vivo and In Vitro Efficacy of Amodiaquine against Plasmodium falciparum in an Area of Continued Use of 4-Aminoquinolines in East Africa
Philip Sasi , Abdi Abdulrahaman , Leah Mwai , Steven Muriithi
The Journal of Infectious Diseases 199 ( 11) 1575 -1582
22
2009
Generation of Transmission-Competent Human Malaria Parasites with Chromosomally-Integrated Fluorescent Reporters.
Kyle Jarrod McLean , Judith Straimer , Christine S. Hopp , Joel Vega-Rodriguez
Scientific Reports 9 ( 1) 13131 -13131
4
2019
Generation of Transgenic Human Malaria Parasites With Strong Fluorescence in the Transmission Stages
Kyle J McLean , Judith Straimer , Christine S Hopp , Joel Vega-Rodriguez
bioRxiv 500793
1
2018
A Worldwide Map of Plasmodium Falciparum K13-Propeller Polymorphisms
Didier Ménard , Nimol Khim , Johann Beghain , Ayola A Adegnika
The New England Journal of Medicine 374 ( 25) 2453 -2464
489
2016
Targeting the Cell Stress Response of Plasmodium falciparum to Overcome Artemisinin Resistance
Con Dogovski , Stanley C. Xie , Gaetan Burgio , Jess Bridgford
PLOS Biology 13 ( 4) e1002132 -573
197
2015
Editing the Plasmodium vivax Genome, Using Zinc-Finger Nucleases
Roberto R. Moraes Barros , Judith Straimer , Juliana M. Sa , Rebecca E. Salzman
The Journal of Infectious Diseases 211 ( 1) 125 -129
18
2015
Genome-wide screen identifies new candidate genes associated with artemisinin susceptibility in Plasmodium falciparum in Kenya
Steffen Borrmann , Judith Straimer , Leah Mwai , Abdirahman Abdi
Scientific Reports 3 ( 1) 3318 -3318
49
2013
Insights into the intracellular localization, protein associations and artemisinin resistance properties of Plasmodium falciparum K13
Nina F. Gnädig , Barbara H. Stokes , Rachel L. Edwards , Gavreel F. Kalantarov
PLOS Pathogens 16 ( 4)
21
2020
A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance
Paul M O’Neill , Richard K Amewu , Susan A Charman , Sunil Sabbani
Nature Communications 8 ( 1) 15159
57
2017
Globally prevalent PfMDR1 mutations modulate Plasmodium falciparum susceptibility to artemisinin-based combination therapies
M. Isabel Veiga , Satish K. Dhingra , Philipp P. Henrich , Judith Straimer
Nature Communications 7 ( 1) 11553 -11553
113
2016
Characterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose-Efficacy Modeling.
Amélie Le Bihan , Ruben de Kanter , Iñigo Angulo-Barturen , Christoph Binkert
PLOS Medicine 13 ( 10) 1 -24
39
2016