Site-Directed Mutations and the Polymorphic Variant Ala160Thr in the Human Thromboxane Receptor Uncover a Structural Role for Transmembrane Helix 4

Raja Chakraborty , Sai Prasad Pydi , Scott Gleim , Shyamala Dakshinamurti
PLoS ONE 7 ( 1) e29996

13
2012
Prostacyclin receptor/thromboxane receptor interactions and cellular responses in human atherothrombotic disease

Scott Gleim , Zsolt Kasza , Kathleen Martin , John Hwa
Current Atherosclerosis Reports 11 ( 3) 227 -235

21
2009
Activation of the α1b-Adrenergic Receptor Is Initiated by Disruption of an Interhelical Salt Bridge Constraint

James E. Porter , John Hwa , Dianne M. Perez
Journal of Biological Chemistry 271 ( 45) 28318 -28323

114
1996
α1-Adrenergic Receptor Subtypes Molecular Structure, Function, and Signaling

Robert M. Graham , Dianne M. Perez , John Hwa , Michael T. Piascik
Circulation Research 78 ( 5) 737 -749

469
1996
Adenylyl cyclase type 6 overexpression selectively enhances β-adrenergic and prostacyclin receptor-mediated inhibition of cardiac fibroblast function because of colocalization in lipid rafts

Xiaoqiu Liu , Muthusamy Thangavel , Shu Qiang Sun , Joseph Kaminsky
Naunyn-schmiedebergs Archives of Pharmacology 377 ( 4) 359 -369

25
2008
Recessive mutations in DGKE cause atypical hemolytic-uremic syndrome

Mathieu Lemaire , Véronique Frémeaux-Bacchi , Franz Schaefer , Murim Choi
Nature Genetics 45 ( 5) 531 -536

316
2013
Arginine (CGC) codon targeting in the human prostacyclin receptor gene (PTGIR) and G-protein coupled receptors (GPCR).

Jeremiah Stitham , Eric J. Arehart , Scott Gleim , Karen Douville
Gene 396 ( 1) 180 -187

15
2007
Relation between age, arterial distensibility, and aortic dilatation in the Marfan syndrome.

Richmond W. Jeremy , Hui Huang , John Hwa , Hugh McCarron
American Journal of Cardiology 74 ( 4) 369 -373

137
1994
Clusters of transmembrane residues are critical for human prostacyclin receptor activation.

Jeremiah Stitham , Aleksandar Stojanovic , Lauren A. Ross , Anthony C. Blount
Biochemistry 43 ( 28) 8974 -8986

22
2004
A Novel Pathway for Nickel-induced Interleukin-8 Expression

Aaron Barchowsky , Nicole V Soucy , Kimberley A O'Hara , John Hwa
Journal of Biological Chemistry 277 ( 27) 24225 -24231

41
2002
The Unique Ligand-binding Pocket for the Human Prostacyclin Receptor SITE-DIRECTED MUTAGENESIS AND MOLECULAR MODELING

Jeremiah Stitham , Aleksandar Stojanovic , Bethany L. Merenick , Kimberley A. O'Hara
Journal of Biological Chemistry 278 ( 6) 4250 -4257

46
2003
Role of Platelet Mitochondria: Life in a Nucleus-Free Zone.

Hannah Melchinger , Kanika Jain , Tarun Tyagi , John Hwa
Frontiers in Cardiovascular Medicine 6 153

20
2019
Differential association between human prostacyclin receptor polymorphisms and the development of venous thrombosis and intimal hyperplasia: a clinical biomarker study.

Paola Patrignani , Concetta Di Febbo , Stefania Tacconelli , Karen Douville
Pharmacogenetics and Genomics 18 ( 7) 611 -620

30
2008
A guide to molecular and functional investigations of platelets to bridge basic and clinical sciences

Tarun Tyagi , Kanika Jain , Sean X Gu , Miaoyun Qiu
Nature Cardiovascular Research 1 ( 3) 223 -237

7
2022
Platelet-derived TLT-1 promotes tumor progression by suppressing CD8+ T cells

Tarun Tyagi , Kanika Jain , Timur O Yarovinsky , Michael Chiorazzi
Journal of Experimental Medicine 220 ( 1) e20212218

2022
Gasdermin D-dependent platelet pyroptosis exacerbates NET formation and inflammation in severe sepsis

Meiling Su , Chaofei Chen , Shaoying Li , Musheng Li
Nature cardiovascular research 1 ( 8) 732 -747

6
2022
TET2 protects against vascular smooth muscle cell apoptosis and intimal thickening in transplant vasculopathy

Allison C Ostriker , Yi Xie , Raja Chakraborty , Ashley J Sizer
Circulation 144 ( 6) 455 -470

15
2021
Gasdermin D inhibition confers antineutrophil-mediated cardioprotection in acute myocardial infarction

Kai Jiang , Zizhuo Tu , Kun Chen , Yue Xu
The Journal of Clinical Investigation 132 ( 1)

24
2022
Histone acetyltransferases p300 and CBP coordinate distinct chromatin remodeling programs in vascular smooth muscle plasticity

Raja Chakraborty , Allison C Ostriker , Yi Xie , Jui M Dave
Circulation 145 ( 23) 1720 -1737

39
2022