Nicholas Valerie
机构: Assistant Professor at Karolinska Institutet and Science for Life Laboratory
主页: researchgate.net
每年引用次数
引用次数
引用: 1,583
H-指数: 15
I10-指数 : 16
出版物: 26
Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies
Nikolas Herold , Sean G Rudd , Linda Ljungblad , Kumar Sanjiv
Nature Medicine 23 ( 2) 256 -263
65
2017
Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion
Sarah E. Golding , Elizabeth Rosenberg , Nicholas Valerie , Isa Hussaini
Molecular Cancer Therapeutics 8 ( 10) 2894 -2902
359
2009
Mutations in the BRCT binding site of BRCA1 result in hyper-recombination
Seth M. Dever , Sarah E. Golding , Elizabeth Rosenberg , Bret R. Adams
Aging 3 ( 5) 515 -532
52
2011
Novel functionalized purine-2, 6-diones and their use in medicine
Brent Page , Nicholas Valerie , Thomas Helleday , Olov Wallner
2021
Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2. Nat Commun. 2015; 6: 7871
M Carter , AS Jemth , A Hagenkort , BD Page
3
Orally Bioavailable and Blood-Brain Barrier-Penetrating ATM Inhibitor (AZ32) Radiosensitizes Intracranial Gliomas in Mice.
Jeremy Karlin , Jasmine Allen , Syed F. Ahmad , Gareth Hughes
Molecular Cancer Therapeutics 17 ( 8) 1637 -1647
19
2018
Inhibition of T-type calcium channels disrupts Akt signaling and promotes apoptosis in glioblastoma cells
Nicholas C.K. Valerie , Barbara Dziegielewska , Amol S. Hosing , Ewa Augustin
Biochemical Pharmacology 85 ( 7) 888 -897
57
2013
ATM kinase inhibition preferentially sensitizes p53 mutant glioma to ionizing radiation.
Laura Biddlestone-Thorpe , Muhammad Sajjad , Elizabeth Rosenberg , Jason M. Beckta
Clinical Cancer Research 19 ( 12) 3189 -3200
129
2013
Pathways Controlling dNTP Pools to Maintain Genome Stability
Sean G. Rudd , Nicholas C.K. Valerie , Thomas Helleday
DNA Repair 44 193 -204
56
2016
NUDT15 Hydrolyzes 6-Thio-DeoxyGTP to Mediate the Anticancer Efficacy of 6-Thioguanine.
Nicholas C.K. Valerie , Anna Hagenkort , Brent D.G. Page , Geoffrey Masuyer
Cancer Research 76 ( 18) 5501 -5511
61
2016
Inhibition of Neurotensin Receptor 1 Selectively Sensitizes Prostate Cancer to Ionizing Radiation
Nicholas C.K. Valerie , Eli V. Casarez , John O. DaSilva , Marya E. Dunlap-Brown
Cancer Research 71 ( 21) 6817 -6826
37
2011
Abstract A239: T-type calcium channels as a novel molecular target for tumor therapy.
Barbara Dziegielewska , Nicholas C.K. Valerie , Amol S. Hosing , James M. Larner
Molecular Cancer Therapeutics 12
2013
NUDT15-mediated hydrolysis limits the efficacy of anti-HCMV drug ganciclovir
Si Min Zhang , Daniel Rehling , Ann-Sofie Jemth , Adam Throup
Cell chemical biology 28 ( 12) 1693 -1702. e6
10
2021
Coupling cellular drug-target engagement to downstream pharmacology with CeTEAM
Nicholas CK Valerie , Kumar Sanjiv , Oliver Mortusewicz , Si Min Zhang
bioRxiv 2022.09. 19.505646 -2022.09. 19.505646
2022
Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells (vol 9, 250, 2018)
Brent DG Page , Nicholas CK Valerie , Roni HG Wright , Olov Wallner
NATURE COMMUNICATIONS 10
2019
Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells.
Brent DG Page , Nicholas CK Valerie , Roni HG Wright , Olov Wallner
Nature Communications 9 ( 1) 250 -250
47
2018
Neurotensin receptor antagonist, SR48692, sensitizes prostate cancer cells to radiation in vitro and in vivo
Eli V Casarez , John O DaSilva , Nicholas CK Valerie , Suresh Anaganti
Cancer Research 71 ( 8_Supplement) 2505 -2505
2011
Duplexed CeTEAM drug biosensors reveal determinants of PARP inhibitor selectivity
Maria J Pires , Alen Lovric , Seher Alam , Emanuele Fabbrizi
bioRxiv 2024.08. 09.607390 -2024.08. 09.607390
2024
Probing intracellular determinants of PARP inhibitor selectivity and pharmacology with CeTEAM
Maria J Pires , Alen Lovric , Emanuele Fabbrizi , Dante Rotili
bioRxiv
2024
Abstract LB-262: Targeting T-type calcium channels induces the extrinsic apoptotic pathway and sensitizes glioblastoma cancer cells to radio- and chemotherapy
Jaroslaw Dziegielewski , Nicholas C. K. Valerie , Barbara Dziegielewska , Amol S. Hosing
Cancer Research 72
1
2012