Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion
作者： Sarah E. Golding , Elizabeth Rosenberg , Nicholas Valerie , Isa Hussaini , Mark Frigerio
DOI: 10.1158/1535-7163.MCT-09-0519
关键词:
摘要: Ataxia telangiectasia (AT) mutated (ATM) is critical for cell cycle checkpoints and DNA repair. Thus, specific small molecule inhibitors targeting ATM could perhaps be developed into …
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