Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo.

摘要: The mitogen-activated protein kinase pathway is thought to be essential in cellular growth and differentiation. Here we report the discovery of a highly potent selective inhibitor upstream MEK that orally active. Tumor was inhibited as much 80% mice with colon carcinomas both mouse human origin after treatment this inhibitor. Efficacy achieved wide range doses no signs toxicity, correlated reduction levels activated excised tumors. These data indicate inhibitors represent promising, noncytotoxic approach clinical management cancer.