Signal Transduction through MAP Kinase Cascades

摘要: Publisher Summary The chapter introduces the mitogen-activated protein (MAP) kinase (MAPK) module. identification of MAP pathways exemplifies power combining biochemical and genetic approaches to molecular problems. discusses mammalian MAPK pathways—ERKl/2 MKKl/2 pathways—and stress-activated pathways. regulation by phosphatases is discussed in describing detail about dual specificity phosphatases, serinenhreonine tyrosine phosphatases. explores cellular substrates kinases, wherein it for MAPKS, nuclear transcription factors, signaling components, cytoskeletal proteins. Responses pathways, cell growth transformation, differentiation development have also been summarized chapter. describes yeast saccharomyces cerevisiae (Budding Yeast) Schizosaccharomyces pombe (Fission Yeast). provides description intracellular targeting spatial pathway complexes, translocation MKK. Eukaryotic cascades provide excellent examples signal transduction mechanisms that embody key principles common many, if not all, Many fundamental questions remain future studies investigate which these are regulated as well responses they control.