The Human Epidermal Growth Factor Receptor (HER) Family: Structure and Function
作者： Federico Cappuzzo
DOI: 10.1007/978-3-319-03059-3_2
关键词: Growth factor receptor inhibitor 、 Extracellular 、 Cell biology 、 Fibroblast growth factor receptor 4 、 Epidermal growth factor receptor 、 Growth factor receptor 、 TGF alpha 、 Gene 、 Biology 、 Receptor
摘要: Epidermal growth factor receptor (EGFR) belongs to a family of four different receptors, including EGFR (ErbB-1; human epidermal 1 [HER1]), HER2 (c-ErbB-2), HER3 (c-ErbB-3), and HER4 (c-ErbB-4). These proteins are coded by distinct genes that expressed on chromosomes 7, 17, 12, 2, respectively. Although specific soluble ligands have been identified for the extracellular domains EGFR, HER3, HER4, no ligand has HER2.
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