Clinicopathologic features and prognostic implications of epidermal growth factor receptor (EGFR) gene copy number and protein expression in non-small cell lung cancer

摘要: Increased epidermal growth factor receptor (EGFR) gene copy numbers and mutations predict sensitivity to EGFR tyrosine kinase inhibitor in non-small cell lung cancer (NSCLC). However, the clinicopathologic features of status NSCLC remain unclear. We retrospectively analyzed 262 cases NSCLC, including 135 squamous carcinomas (SCC) 112 adenocarcinomas (ADC), for which paraffin blocks resected primary mass were available. None had received EGFR-targeted therapy. number was evaluated using fluorescence situ hybridization (FISH), expression determined immunohistochemically a tissue microarray. A high (EGFR FISH-positive) found 30.2% (amplification 11.1% polysomy 19.1%). There no significant difference FISH with respect SCC ADC histology. The FISH-positive rate higher non-smokers than smokers multivariate analysis (p=0.012). significantly associated histology (p=0.000). In univariate survival analysis, FISH-positivity predicted worse (p=0.059), especially stage I (p=0.04). amplification shorter node-positive (p=0.015). or protein influence on prognosis ADC. conclusion, Korean patients similar rates Western populations, unlike frequencies mutation East Asians. more common non-smokers, as mutations. SCC; therefore, prognostic implications should be context staging NSCLC.