Survival impact of epidermal growth factor receptor overexpression in patients with non-small cell lung cancer: a meta-analysis

摘要: Background: It is thought that overexpression of epidermal growth factor receptor (EGFR) in non-small cell lung cancer (NSCLC) might compromise patient survival, presumably by promoting tumour an autocrine mechanism. However, conflicting results have been reported from various laboratories, and the clinical importance EGFR remains unsettled. Methods: A meta-analysis previous studies was performed to quantitatively review effects on survival patients with NSCLC using a DerSimonian-Laird random model. Eighteen including 2972 were subjected final analysis. Results: Overall, positivity for differed between histological types: 39% adenocarcinomas, 58% squamous carcinomas, 38% large 32% cancers miscellaneous category (p<0.0001). The combined hazard ratio (HR) 1.14 (95% CI 0.97 1.34; p = 0.103), indicating has no significant impact survival. When only 15 immunohistochemistry based considered, HR 1.08 0.92 1.28; p = 0.356), again suggesting Heterogeneity testing indicated there heterogeneity but publication bias absent, which suggests summary statistics obtained may approximate actual average. Conclusions: not associated poorer NSCLC. Specific mutations gene will need further study terms implications.