Targeted Therapy in Non-Small Cell Lung Cancer

摘要: Despite advances in standard therapies and chemotherapeutic regimens, survival remains poor for patients with lung cancer, the leading cause of cancer death world. Consequently, there is substantial interest identifying potentially exploitable new targets cancer. Over past 5 years, targeted have become firmly established as therapeutic options non-small-cell The epidermal growth factor receptor inhibitors vascular endothelial proven activity rapidly gained widespread use. It anticipated that usefulness additional classes agents will be near future. Of particular importance are effective against tumor cells resistant to chemotherapy. Several currently under investigation, including histone deacetylase inhibitors, DNA-methyltransferase proapoptotic agents, antagonize antiapoptosis molecules, heat shock protein hypoxia-inducible factor-1α antagonists, among others. Further development these approaches awaited interest.