Granulocyte chemotactic protein/interleukin-8 induces plasma leakage and neutrophil accumulation in rabbit skin.

摘要: Abstract Granulocyte chemotactic protein/Interleukin-8 (GCP/IL-8), purified to homogeneity from endotoxin- or mitogen-stimulated human mononuclear cells, was injected intradermally into rabbits evaluate the proinflammatory properties of this novel cytokine. In presence a vasodilator substance, pmol amounts GCP/IL-8 induced neutrophil accumulation that fast in onset, relatively short duration (half life 60 70 minutes), and associated with parallel time course plasma protein extravasation. GCP/IL-8-induced edema formation found be dependent. These data provide evidence fulfills two important criteria for consideration as an inflammatory mediator. It is possible endogenous GCP/IL-8, if produced locally by tissue macrophages, may contribute initiation response infection.