Epidermal growth factor receptor expression correlates with poor prognosis in non-small cell lung cancer patients with p53 overexpression.

摘要: To determine whether cancer patients with tumor suppressor gene abnormality survive for a shorter time when their growth was stimulated by factors, we examined 290 non-small cell lung (NSCLC) specimens p53 and epidermal factor receptor (EGFR) protein expressions using immunohistochemical staining. The distribution of cases pathological stage 155 I, 30 II, 96 III 9 IV. Pathological types were 142 adenocarcinomas, 127 squamous carcinomas, 17 large carcinomas 4 other malignancy. Immunohistochemical staining performed on the formalin fixed, paraffin-embedded materials monoclonal antibodies DO-7 clone EGFR.133. positive EGFR seen in 124 (42.8%) cases. More found than non-squamous (p=0.0121). Staining observed 147 (50.7%) specimens. Multivariate proportional hazard model analyses revealed expression as risk NSCLC (p=0.0240). Patients negative both survived longer period (p=0.0427).