Molecular and Cell Biology of Lung Carcinoma

摘要: Lung carcinoma is currently perceived to be the result of complex mutational and epigenetic changes in epithelial cells lung that impart those a high capacity for proliferation, resistance programmed cell (apoptosis), ability invade destroy normal tissue metastasize. cancer achieve these properties through series genomic are highly heterogeneous with respect timing their occurrence, complexity, anatomic location affected specific molecular pathways affected. Defining changes, devising methods measuring them large patient populations taking advantage therapeutic protocols will continue most daunting challenges research foreseeable future. In recent years, there has been increase available cellular information this field. This review attempts relate well-established data clinical problem premalignancy. Numerous references referring more detailed reviews provided convenience interested further reading.