摘要: Lung cancer is the commonest cause of death in western world. Recent evidence suggests that angiogenesis related to poor prognosis many solid tumours including non-small cell lung cancer. Angiogenesis controlled by a complex interaction between growth and apoptotic factors, proteases adhesion molecules. The angiogenic process may prove target for novel therapies such as matrix metalloproteinase inhibitors, factor antisense RNA, receptor antagonists naturally occurring antiangiogenic peptides. These agents be used alone or combination with traditional chemotherapy, radiotherapy surgery.
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