Molecular genetics of lung and pleural neoplasms

摘要: Molecular pathology involves study of nucleic acids, genes, and gene products. The development progression human cancers are linked to genetic instability the accumulation multiple mutations, which can be investigated with tools molecular pathology. provides a basis for understanding biology lung cancer, including its pathogenetic relationship tobacco smoking, increasingly is providing targets therapeutic intervention. In this section, we briefly review basic terminology concepts, as an introduction or refresher subsequent sections chapter, discuss products; replication, translation, transcription; posttranslational modifications products protein degradation; transcription factors, cell surface receptors signaling pathways, cycle, apoptosis, survival DNA damage repair; mutations; microRNAs siRNAs.