Phosphatidylinositol-3 kinase dependent pathways: the role in control of cell growth, survival, and malignant transformation.

摘要: Phosphatidylinositol-3 kinase (PI3K) is one of the most important regulatory proteins that involved in different signaling pathways and controlling key functions cell. The double-enzymatic activity PI3K (lipid protein kinase) as well ability this enzyme to activate a number signal including some oncoproteins determines its fundamental significance regulation cell such growth survival, aging, malignant transformation. Among main effectors are mitogen-transducing (protein C, phosphoinositide-dependent kinases, small G-proteins, MAP (mitogen activated protein) kinases), which either via their interaction with lipid products or through PI3K-dependent phosphorylation proteins. anti-apoptotic effect realized by activation from another pathway--protein B (PKB) and/or PKB-dependent enzymes (GSK-3, ILK). plays critical role itself possesses oncogenic also forms complexes viral cellular (src, ras, rac, alb, T-antigen), whose transforming activities only presence PI3K. supposed occur on basis complex alterations pathways: appearance constitutively generated mitogen protooncogenes etc.), PI3K/PKB-pathway stimulation resulting delay apoptosis increase actin cytoskeleton reorganization.