Local erythropoietin signaling enhances regeneration in peripheral axons.

摘要: Erythropoietin (EPO) and its receptor (EPO-R), mediate neuroprotection from axonopathy apoptosis in the peripheral nervous system (PNS). We examined impact potential mechanisms of local EPO signaling on regenerating PNS axons vivo vitro. As a consequence injury, nerve DRG neurons have marked increase expression EPO-R. Local delivery via conduit over 2 weeks to rat sciatic following crush injury increased density maturity myelinated growing distally site. In addition, also rescued retrograde degeneration atrophy axons. substantially intensity calcitonin gene-related peptide (CGRP) within outgrowing Behavioral improvements sensorimotor function occurred rats exposed near delivery. led decreased nuclear factor kappaB (NFkB) activation but phosphorylation Akt STAT3 dorsal root ganglia indicating rescue an phenotype. Spinal cord explant studies demonstrated similar dose-dependent effect upon motor axonal outgrowth. enhances addition known neuroprotection. Exogenous may therapeutic role large number diseases through regeneration.